Gouri Yogalingam

PyraBio, Inc
United States

Lynn Cronomiz

Alzheimer's Impact Movement
United States

Rich Kronish

Laurie Sotro

Filling in the Family Tree—AD, CTE Folds Spotted in Other Tauopathies

RESEARCH NEWS 2025-03-27 Research News Eight years ago, people were amazed by the first high-resolution glimpse into the core of tau fibrils extracted from the brain of a person who had had Alzheimer’s disease. Since those iconic back-to-back C-shaped structures came into view, s

Vincent Tse

Yale School of Medicine

PAPER Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, vanSwieten JC, Ghetti B, Scheres SH, Goedert M

Novel tau filament folds in individuals with MAPT mutations P301L and P301T

bioRxiv2024.08.15.608062 .

Mike Miguel Pappolla on The Bad Medicine of Doctored

COMMENT Charles Piller’s book "Doctored" wrongly portrays Alzheimer’s disease research as largely fraudulent, dramatically misrepresenting decades of rigorous scientific effort. While misconduct in science is reprehensible, Piller inaccurately extrapola

Jonathan Schott on Is Dementia Incidence Still Dropping? Birth Cohort Data Say Yes.

COMMENT This paper by Stallard and colleagues models extant data over a 40-year period to predict future trends in dementia in the U.S., concluding that the prevalence of dementia may be substantially lower in the future than has previously been estimated. This p

Helena Blumen on Age and cognitive skills: Use it or lose it.

COMMENT Age-related changes in literacy and numeracy skills were thoughtfully examined by Hanushek and colleagues in a large, longitudinal, and representative sample of German adults aged 16-65 years. Interestingly, they found that literacy and numeracy skills co

Helena Blumen

Stony Brook Medicine

PSEN1 F386L (T> C)

MUTATIONS PSEN1 73217152 GRCh38/hg38 T C 73683860 GRCh37/hg19 T C Exon 11 Coding Unknown, but in silico algorithm predicted it is deleterious (PHRED-scaled CADD = 25.8). Unknown. F386L (T>C) Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detail

PAPER Armbrust F, Bickenbach K, Koudelka T, Joos C, Keller M, Tholey A, Pietrzik CU, Becker-Pauly C

HYTANE-Identified Latrophilin-3 Cleavage by Meprin β Leads to Loss of the Interaction Domains.

J Proteome Res. 2025 Mar 26; Epub 2025 Mar 26 PubMed.

PAPER Bae M, Kim N, Cho E, Lee T, Lee JH

Recent Advances in Electrochemical Biosensors for Neurodegenerative Disease Biomarkers.

Biosensors (Basel). 2025 Feb 28;15(3) PubMed.

PAPER Wu Y, Guo Q, Gan J, Duan L, Zhao H, Tai H, Yang C, Li Y, Xu Z, Yao Y, Nie Z, Yang M, Li S, Li J, Su B

Dynactin knockdown leads to synuclein aggregation by blocking autophagy in a zebrafish model of Parkinson's disease.

Braz J Med Biol Res. 2025;58:e14282. Epub 2025 Mar 24 PubMed.