347549 RESULTS
RESEARCH NEWS 1998-09-10 Research News A study published in tomorrow's Science provides new details of how the transcription factor NF-κB protects cells from apoptosis. C.-Y. Wang and colleagues report they have identified four genes that are targets of NF-κB activity. The g
RESEARCH NEWS 1998-09-06 Research News A novel brain-imaging agent that binds selectively to dopamine transporter molecules promises to open up a window on the functioning of the brain's dopamine system. Dopamine is one of the brain's major neurotransmitters, and is imp
RESEARCH NEWS 1998-09-05 Research News Puny polymer pellets show promise as a vehicle for delivering nerve-growth factor (NGF) to the basal forebrain, where the substance could rescue or even regenerate neurons damaged by Alzheimer's disease. For some years, the idea of intr
RESEARCH NEWS 1998-09-03 Research News A 15-year study involving more than 100 families and 1,000 individuals has provided the first strong evidence of genetic susceptiblity to schizophrenia, within a stretch of chormosome 13. According to the international team, led by Ann Pulve
RESEARCH NEWS 1998-09-03 Research News The growing tips, or growth cones, of neurons are confronted with a chemical cacophany of growth-guiding cues. How do they know which ones to heed? In an article appearing in Science (4 September issue), H.-J. Song and colleagues report that
RESEARCH NEWS 1998-09-02 Research News For many families caring for an Alzheimer's patient, it is not the memory impairment per se that drives them to place their loved one in a nursing home, so much as the agitation, aggression and even violence that demented patients frequ
RESEARCH NEWS 1998-08-20 Research News Stress and glucocorticoids (hormones produced in response to stress) are known to impair the acquisition and storage of new information. But stress also hinders the ability to recall memories, according to a study published by Benno Roozenda
RESEARCH NEWS 1998-08-20 Research News It has been theorized that cell membranes contain stable regions consisting of glycolipids and cholesterol. They are called detergent-insoluble glycolipid-enriched membrane domains (DIGs), or, more picturesquely, "rafts." These raf
RESEARCH NEWS 1998-08-14 Research News Transcription factors of the nuclear factor-kB/rel (NF-kB) family may be important in cell survival by regulating unidentified, antiapoptotic genes. One such gene that protects cells from apoptosis induced by Fas or tumor necrosis factor typ
RESEARCH NEWS 1998-08-14 Research News Acetylcholine has different effects on the excitability of different neuronal types, according to work by Xiang, et al, published in today's Science. The researchers examined two subtypes of interneurons in layer V of rat visual cortex.
RESEARCH NEWS 1998-08-14 Research News Maybe it is time to give up steak in order to live longer—at least if you are a fruit fly. According to a study published today in Science, a diet of sugar keeps flies in a metabolic "waiting mode," in which both reproduction and d
RESEARCH NEWS 1998-08-13 Research News An enzyme in Caenorhabditis elegans affects the rate at which the dainty worms age, by modulating the cellular response to oxidative stress. In today's Nature, Naoaki Ishii and his colleagues at the Tokai University School of Medicine,
COMMENT As a quick comment regarding Luc Buee's summary of Dr. Lindsay Farrer's talk on the genetics of AD and chromosome 12 in the Genetics I session of the Sixth Int. Conference on AD in Amsterdam, Dr. Buee reports that Dr. Farrer's genetic linka
COMMENT Dr. Lukiw does not mention that Dr. Peggy Vance reported that she replicated our significant genetic association of A2M and AD using the same A2M polymorphism (exon 18 deletion) in the same AD families (NIMH AD family set N = ~350) that we used and with t
COMMENT Dear Dr. Kosik, It was an honor that our work, presented at the Sixth International Conference on AD, was described in your briefing about presenilin-binding proteins. Similarly to your team and the identification of the catenins as possible modulators of
