PAPER Zheng Y, Yang J, Li X, Qi L, Zheng Z, Kong J, Zhang G, Guo Y
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347546 RESULTS
Fragments of Tau’s Microtubule Binding Region Mess with Synapses
RESEARCH NEWS 2025-03-06 Research News When under stress, neurons crank out tau fragments, and many scientists blame this for the propagation of tangle pathology in Alzheimer’s disease. The fragments also directly compromise synapses they encounter along the way, according to a p
Kanta Horie on Fragments of Tau’s Microtubule Binding Region Mess with Synapses
COMMENT This study investigated what tau species are capable of inducing synaptotoxicity, by measuring LTP in rats injected with AD brain extracts or with secretomes of iPSC-derived neurons from individuals with Down’s syndrome. The study design includes the immu
PAPER Ondrejcak T, Hu N-W, Coode E, Campbell T, Corbett GT, Doykov I, Mills K, Walsh DM, Livesey FJ, Rowan MJ, Klyubin I
Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region
bioRxiv2025.02.21.639417 .PAPER Qi C, Lövestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SH, Goedert M
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.
Nat Struct Mol Biol. 2025 Mar 5; Epub 2025 Mar 5 PubMed.Can Autoimmunity Spark Alzheimer’s Disease?
RESEARCH NEWS 2025-03-06 Research News Alzheimer’s may be, at least in part, a disease of the immune system. Evidence supporting this comes from the study of genetics, infectious diseases, and the molecular machinations of the innate and adaptive immune systems in the brain. Now,
Michael Guo on Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease.
COMMENT The authors leverage cutting-edge tools to large sequencing datasets in order to examine Variable Number Tandem Repeats, which, given their repetitive nature, have been traditionally very challenging to study at scale. The authors find multiple VNTRs that
PAPER Heath A, McNerney MW, Yesavage J
Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease.
Neurol Genet. 2025 Apr;11(2):e200241. Epub 2025 Feb 14 PubMed.Donald Weaver on Can Autoimmunity Spark Alzheimer’s Disease?
COMMENT This paper contributes significantly to our understanding of the role of dysregulated adaptive immunity in the pathogenesis of Alzheimer’s disease. It represents a significant body of knowledge regarding how autoimmunity may contribute to AD risk. The aut
Rebecca Wallings
Indiana UniversityUnited States
Elaine Lim on Can Autoimmunity Spark Alzheimer’s Disease?
COMMENT I believe this is among the first, if not the first, large-scale, systematic study of electronic medical records (EHR) testing associations between Alzheimer’s and 26 autoimmune diseases. I found the paper super interesting because several studies have re
Chun Keung Shum
PAPER Buchholz E, Machule ML, Buthut M, Stefanovski L, Rössling R, Prüss H
Overlapping presence of β-amyloid, tau, p-tau, and α-synuclein in skin nerve fibers in Alzheimer's disease.
J Neurol. 2025 Mar 5;272(3):247. PubMed.PAPER Abdeen AH, Trist BG, Nikseresht S, Harwood R, Roudeau S, Rowlands BD, Kreilaus F, Cottam V, Mor D, Richardson M, Siciliano J, Forkgen J, Schaffer G, Genoud S, Li AA, Proschogo N, Antonio B, Falkenberg G, Brueckner D, Kysenius K, Liddell JR, Fat SC, Wu S, Fifita J, Lockwood TE, Bishop DP, Blair I, Ortega R, Crouch PJ, Double KL
Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model.
Acta Neuropathol. 2025 Mar 5;149(1):22. PubMed.PAPER Reho P, Kalia V, Jackson GL, Wang F, Eiten E, Brennan K, Brickman AM, Mayeux R, Miller GW, Vardarajan BN, Baccarelli A, Wu H
Preclinical Alzheimer's disease shows alterations in circulating neuronal-derived extracellular vesicle microRNAs in a multiethnic cohort.
Alzheimers Dement. 2025 Mar;21(3):e70050. PubMed.Current Filters
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