347506 RESULTS
COMMENT This paper is a massive accomplishment, representing the most robust evidence yet of female-specific vulnerability to tau aggregation. Applying a meta-analytic approach, the authors pooled estimates across six studies, including more than 1,300 participan
COMMENT This strikes me as a thoughtful and rigorous effort to improve our understanding of the apparent increased risk of having a diagnosis of AD in women than men, the reasons for which are not fully elucidated. The authors make a compelling case that women ex
RESEARCH NEWS 2025-03-12 Research News Numerous studies have hinted that women are particularly susceptible to tau pathology, but scientists have lacked definitive data. Now, a meta-analysis of six longitudinal tau PET studies offers the strongest evidence yet. In the March 3 JAM
COMMENT This meta-analysis by Coughlan et al. provides robust evidence across six longitudinal cohorts, showing that women accumulate tau pathology faster than men in preclinical AD. This work is of high clinical relevance, as the transition from amyloidosis to t
PAPER Xu X, Kwon J, Yan R, Apio C, Song S, Heo G, Yang Q, Timsina J, Liu M, Budde J, Blennow K, Zetterberg H, Lleó A, Ruiz A, Molinuevo JL, Lee VM, Deming Y, Heslegrave AJ, Hohman TJ, Pastor P, Peskind ER, Albert MS, Morris JC, Park T, Cruchaga C, Sung YJ
United States
COMMENT I commend the authors for their exceptional characterization of the novel PET probe [18F]FEDV, which shows strong potential for detecting reactive oxygen species (ROS) in models of stroke and tauopathy. The validation of [18F]FEDV using dihydroethidium, t
Rush University Medical CenterUnited States
Children's Hospital of Philadelphia
Brazil
University of Eastern FinlandFinland
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, GermanyGermany
UT Health San Antonio
COMMENT I congratulate the authors for trying to develop an alternative strategy to imaging reactive oxygen and reactive nitrogen species (ROS/RNS) in vivo with PET. Our group developed the radiotracer, [18F]ROStrace, and we have conducted PET imaging studies to
PAPER Gallagher E, Li S, Lee H, Xu H, Lee VMY, Mach RH, McManus MJ
