PAPER Xu X, Kwon J, Yan R, Apio C, Song S, Heo G, Yang Q, Timsina J, Liu M, Budde J, Blennow K, Zetterberg H, Lleó A, Ruiz A, Molinuevo JL, Lee VM, Deming Y, Heslegrave AJ, Hohman TJ, Pastor P, Peskind ER, Albert MS, Morris JC, Park T, Cruchaga C, Sung YJ

Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries.

JAMA Netw Open. 2025 Mar 3;8(3):e250562. PubMed.

Meagan McManus on A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.

COMMENT I commend the authors for their exceptional characterization of the novel PET probe [18F]FEDV, which shows strong potential for detecting reactive oxygen species (ROS) in models of stroke and tauopathy. The validation of [18F]FEDV using dihydroethidium, t

Meagan McManus

Children's Hospital of Philadelphia

Salete Lopes Ribeiro

Brazil

Sami Heikkinen

University of Eastern Finland
Finland

Davina Biel

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany
Germany

Eva Beckett

UT Health San Antonio

Robert Mach on A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.

COMMENT I congratulate the authors for trying to develop an alternative strategy to imaging reactive oxygen and reactive nitrogen species (ROS/RNS) in vivo with PET. Our group developed the radiotracer, [18F]ROStrace, and we have conducted PET imaging studies to

PAPER Gallagher E, Li S, Lee H, Xu H, Lee VMY, Mach RH, McManus MJ

Noninvasive Detection of Oxidative Stress in a Mouse Model of 4R Tauopathy via Positron Emission Tomography with [18F]ROStrace

Int. J. Mol. Sci. 2025 . International Journal of Molecular Sciences

Pierre Tariot on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients

COMMENT This strikes me as a thoughtful and rigorous effort to improve our understanding of the apparent increased risk of having a diagnosis of AD in women than men, the reasons for which are not fully elucidated. The authors make a compelling case that women ex

Giulia Albertini

VIB/KU Leuven
Belgium

PAPER Liou JJ, Li J, Berardinelli J, Jin H, Santini T, Noh J, Farhat N, Wu M, Aizenstein HJ, Mettenburg JM, Yong WH, Head E, Ikonomovic MD, Ibrahim TS, Kofler JK, Alzheimer Biomarker Consortium—Down Syndrome

Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer's disease and related neurodegenerative pathologies using 7T postmortem MRI.

J Neuropathol Exp Neurol. 2025 Mar 10; Epub 2025 Mar 10 PubMed.

David Hilbert

University of Illinois Chicago
United States

PSEN1 S170del (delTCT)

MUTATIONS PSEN1 73653588_73653590 GRCh37/hg19 TCT--- 73186880_73186882 GRCh38/hg38 TCT--- Exon 6 Coding Unknown, although a variant resulting in S170 deletion (DNA change unknown) resulted in an increased Aβ42/Aβ40 ratio and a decreased Aβ37/42 ratio in cells. Unkn

Maria Consuelo Segura Delgado

, Peru