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Studying Diverse Populations May Require New Biomarkers

CONFERENCE COVERAGE 2025-02-15 Conference Coverage Although efforts to identify biomarkers for Alzheimer's disease are advancing rapidly, many still struggle to obtain information from populations other than non-Hispanic white people. At the Human Amyloid Imaging (HAI) conference,

When Tau Wanders Off, Subcortical Axon Firing Goes Mum

CONFERENCE COVERAGE 2025-02-15 Conference Coverage When it comes to tau tangles, cortical deposits receive the lion’s share of scientists’ attention, but it is the tiny subcortical regions where tangles originate that might set the course for Alzheimer's. New data presented at the

At Human Amyloid Imaging Conference, Plasma Tau Was the Star

CONFERENCE COVERAGE 2025-02-14 Conference Coverage The hunt for blood-based biomarkers is continuing apace. At the Human Amyloid Imaging (HAI) meeting, held January 15-17, researchers focused on new techniques—all based on tau and blood, conference title notwithstanding—for identifying

'Presymptomatic AD' or 'Asymptomatic at Risk'? Dx Criteria Disagree

CONFERENCE COVERAGE 2024-11-27 Conference Coverage As diagnostic criteria for Alzheimer’s disease are being refined, the U.S. and Europe have taken different paths. Broadly speaking, leading clinicians in the U.S. use Alzheimer’s Association criteria, while those in Europe hew to recom

Just as Sharp: MRI Scans at Triple the Speed

CONFERENCE COVERAGE 2024-11-22 Conference Coverage What if there were a way to triple the speed of MRI scans without losing resolution? At the Clinical Trials on Alzheimer’s Disease conference, held October 29 to November 1 in Madrid, Miguel Rosa-Grilo of University College London pres

Beyond Antibodies: From CTAD, New Attempts at Outflanking Alzheimer’s

CONFERENCE COVERAGE 2024-11-22 Conference Coverage Most Alzheimerologists agree that lecanemab and donanemab are a start, but insufficient to treat this disease. At the Clinical Trials in Alzheimer’s Disease conference, held last month in Madrid, scientists not only debated how to make

Some Alzheimer’s Blood Tests Are Racing Toward IVD Certification

CONFERENCE COVERAGE 2024-11-21 Conference Coverage Yes, blood tests for Alzheimer’s disease are ready for prime time. So pronounced Suzanne Schindler, Washington University, St. Louis, in a keynote presentation at CTAD 2024 last month in Madrid. In answering a question that has been ra

Fully Loaded: Secondary Prevention Studies of Lecanemab, Donanemab

CONFERENCE COVERAGE 2024-11-15 Conference Coverage Anti-amyloid antibodies lecanemab and donanemab are in clinical use now, but that does not mean research on them has stopped. At the Clinical Trials on Alzheimer’s Disease conference, held October 29-November 1 in Madrid, speakers upda

Tau Modification Drugs Take a Hit with Negative Trial

CONFERENCE COVERAGE 2024-11-14 Conference Coverage While anti-tau antibodies are beginning to look promising (see previous story), small molecules that modify tau proteins haven’t yet fared well in clinical trials. At the 16th Clinical Trials on Alzheimer’s Disease conference, held Oct

Finally, Therapeutic Antibodies Start to Reduce Tangles

CONFERENCE COVERAGE 2024-11-14 Conference Coverage The fifth time may be the charm for antibodies targeting tau. At the 16th Clinical Trials on Alzheimer’s Disease conference, held October 29 to November 1 in Madrid, Brussels-based UCB Pharma presented the first signal that a monoclona

Leqembi: Side Effects No Worse in Clinical Use Than They Were in Trial

CONFERENCE COVERAGE 2024-11-14 Conference Coverage Lecanemab has been in clinical use in the U.S. for nearly two years, and in Japan for not quite a year. How is it going? At the Clinical Trials on Alzheimer’s Disease conference, held October 29 through November 1 in Madrid, speakers o

Donanemab: Small Tweak in Titration, Big Gain in Safety?

CONFERENCE COVERAGE 2024-11-08 Conference Coverage Seeking ways to improve the safety of anti-amyloid antibodies, John Sims of Eli Lilly & Company presented a simple option to do so for donanemab  at this year’s Clinical Trials on Alzheimer’s Disease conference, held October 29-Nov

Trontinemab Data Strengthen Hope for Brain Shuttles

CONFERENCE COVERAGE 2024-11-08 Conference Coverage Fewer than 1 percent of amyloid-targeted monoclonal antibodies like lecanemab and donanemab reach their targets in the brain. The excess doses required to make up for this problem raise the risk of hazardous brain bleeding, reflected i

MODEL-AD Probably Has Something for You

CONFERENCE COVERAGE 2024-09-19 Conference Coverage Alzheimer’s is a multifaceted disease, particularly in its sporadic, late-onset form. Myriad factors—genetics, environment, cardiovascular health, metabolism, and inflammation—contribute to a decades-long process. Generating animal mod

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