340317 RESULTS
COMMENT Genetics studies point to endo-lysosomal, immune, and lipid pathways as dysfunctional in AD, and many of these genes are highly expressed in glia. In this study, Kaji et al., perform an impressive amount of experiments to show microglial cells are necessa
COMMENT The current work is built on the creation of a knock-in mouse model expressing a HaloTag-tagged APOE, thus allowing its in situ visualization and biochemical purification. Using this elegant system, coupled with various imaging modality and biochemical me
COMMENT Kaji et al. propose that fibrillar ApoE—likely forming in microglia lysosomes after internalization and delipidation of the lipid carriers—promotes aggregation of Aβ. The authors preaggregated HFIP Aβ by incubating a solution in PBS for 48 hours at 37°C,
COMMENT This study investigates Aβ plaque pathology through a new mass spectrometry imaging method combined with isotope labeling (iSILK) in an Aβ knock-in mouse model (AppNL-F), and couples the plaque age with spatial transcriptomics. This approach enables the s
COMMENT This study elegantly places a timetable on plaque formation in a transgenic mouse model (AppNL-F) selected to develop amyloid pathology relatively slowly, using stable isotope labeling, mass spectrometry, advanced microscopy and spatial transcriptomic ana
JOB 2024-10-29 Employer University of California, Irvine Contact margarrd@uci.edu To apply, candidates should submit a curriculum vitae, a three-page research statement detailing their area of expertise, the significance of their contributions, and a plan for their futu
JOB 2024-11-01 Employer University of California, San Francisco Contact Please e-mail decisionlab@ucsf.edu with your CV, cover letter, and names and contact information for three references. Informal inquiries are welcome. Applications will be reviewed on an ongoing bas
MUTATIONS MAPT 17:45983334 GRCh38/hg38 rs533610448 A T Exon 4a Coding Unknown. In silico predictions were mixed; PHRED-scaled CADD was below the threshold for deleteriousness (15.48). Unknown, but brain imaging indicates heterogeneity, including frontal and tempora
RESEARCH NEWS 2024-10-30 Research News Scientists broadly agree that both apolipoprotein E and microglia are necessary ingredients for amyloidosis. In mice devoid of ApoE, or of their microglia, scant plaques form. Now, a sweeping study published October 9 in Immunity unveils a m
RESEARCH NEWS 2024-10-29 Research News Far from a static barrier, the brain’s extensive interface with the blood is increasingly being appreciated as an active border, one that serves not only to keep some proteins out, but to let others in (Oct 2024 conference news). Once across
RESEARCH NEWS 2024-10-31 Research News TMEM106b’s rap sheet is growing. Some of its genetic variants are linked to both Alzheimer’s disease and frontotemporal dementia, and fibrils of this lysosomal protein accumulate in several neurodegenerative diseases. Now, in an October 18 p
PAPER Pappolla MA, Refolo L, Sambamurti K, Zambon D, Duff K
JOB 2024-11-04 Employer MRC Laboratory Of Molecular Biology Principal Principal Investigator Benjamin Ryskeldi-Falcon Contact To apply and access full details of the vacancy please visit the job board at https://mrc.tal.net/vx/appcentre-ext/spa-1/candidate/post/5744/en-
SERIES If you listen to National Public Radio, watch TV, or surf the Web, chances are you have come across commercials enticing you to “improve your memory” and “unlock your inner genius” with “brain training developed by neuroscientists.” In search of solid ev
SERIES The rarest kind of Alzheimer's disease, the form that is inherited from parent to child with a cruel 50 percent likelihood, has long been marked by its untapped opportunities. Affected families have made possible both the discovery of the first three
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