Jobs
Postdoctoral Scientist - Neurobiology
Posted 04 Nov 2024
Employer
MRC Laboratory Of Molecular Biology Principal
Location
Cambridge, England, United Kingdom
Principal Investigator
Contact
To apply and access full details of the vacancy please visit the job board at https://mrc.tal.net/vx/appcentre-ext/spa-1/candidate/post/5744/en-GB
If you are unable to apply online please contact us at recruit@mrc-lmb.cam.ac.uk.
Description
Salary £39,375 per annum
Fixed term, three years
The LMB is seeking two postdoctoral scientists to join the group of Benjamin Ryskeldi-Falcon to investigate TDP-43 and annexin A11 amyloid filament formation in neurodegenerative diseases. The first project will focus on determining the structures and molecular interactions of these filaments using electron cryo-microscopy (cryo-EM) and electron cryo-tomography (cryo-ET). The second project involves developing experimental models that recapitulate TDP-43 and annexin A11 amyloid filament formation, allowing for the study of molecular mechanisms and their roles in neurodegeneration.
These projects build on recent findings that TDP-43 forms amyloid filaments with disease-characteristic folds and that annexin A11 forms heteromeric amyloid filaments with TDP-43 in at least one type of frontotemporal dementia.
The LMB seeks motivated team players to pursue ambitious cryo-EM projects on amyloids in neurodegenerative diseases. Candidates should hold a Ph.D. or be due to complete a Ph.D. in six months. Expertise in any of cryo-EM (SPA/ cryo-ET/ cryo-CLEM), amyloids, neuronal/ glial cell culture and neurodegenerative disease models is an advantage. You will become part of our collaborative and supportive group and will benefit from additional interactions with the wider multi-disciplinary scientific community at the LMB.
Group web site: https://www2.mrc-lmb.cam.ac.uk/group-leaders/benjamin-falcon/.
The two positions are three-year training and development positions suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.
The LMB is a world-class research institute within UK Research and Innovation (UKRI). UKRI is nine research councils, working together across all disciplines and sectors. More information can be found at www.ukri.org and www.mrc-lmb.cam.ac.uk.
Closing date: 02/12/2024
Final appointments will be subject to a pre-employment screening.
The LMB actively supports equality, diversity and inclusion in all its activities, processes and culture. It encourages applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under-represented.
The LMB is a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require; recruit@mrc-lmb.cam.ac.uk.