Modern Microscopy

SERIES Modern Microscopy Skims Surface of Living Minds and Spines Modern Microscopy Plumbs the Depths of Brain Tissue

PAPER Shimohama S, Fujioka R, Mihira N, Sekiguchi M, Sartori L, Joho D, Saito T, Saido TC, Nakahara J, Hino T, Hoshino A, Sasaguri H

The Icelandic mutation (APP-A673T) is protective against amyloid pathology in vivo.

J Neurosci. 2024 Nov 4; Epub 2024 Nov 4 PubMed.

PAPER Walker KA, An Y, Moghekar A, Moaddel R, Duggan MR, Peng Z, Tian Q, Pilling LC, Drouin SM, Espeland MA, Rapp SR, Hayden KM, Shadyab AH, Casanova R, Thambisetty M, Rapp PR, Kapogiannis D, Ferrucci L, Resnick SM

Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience.

Mol Neurodegener. 2024 Oct 31;19(1):81. PubMed.

Amyloid Plaques Turn More Toxic as They Age

RESEARCH NEWS 2024-10-25 Research News How exactly do amyloid plaques affect surrounding brain tissue, and does this change over time? Scientists led by Jörg Hanrieder at the University of Gothenburg, Sweden, tackled this question by using isotopically labeled Aβ to timestamp pla

Update on DIAN, API, A4: All About Biomarkers, Trials, and Funds

SERIES Alzforum readers who follow the science of preclinical Alzheimer's and prevention may have heard about three independent but complementary programs that together are laying the groundwork for secondary prevention trials across the spectrum of rare to

PAPER Young AL, Bocchetta M, Russell LL, Convery RS, Peakman G, Todd E, Cash DM, Greaves CV, van Swieten J, Jiskoot L, Seelaar H, Moreno F, Sanchez-Valle R, Borroni B, Laforce R Jr, Masellis M, Tartaglia MC, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler C, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Williams SC, Alexander DC, Rohrer JD, Genetic FTD Initiative (GENFI)

Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling.

Neurology. 2021 Aug 31;97(9):e941-e952. Epub 2021 Jun 22 PubMed.

Learn the Skinny on iPS Cells in Neurodegenerative Disease

SERIES Are you curious about trying iPS cell lines to model the disease you care about? Intrigued but nebulous on where the field is at? Ready to grow an iPS line but not sure where to turn? Read Madolyn Rogers's four-part series to learn all about who does