339075 RESULTS
RESEARCH NEWS 1998-09-02 Research News For many families caring for an Alzheimer's patient, it is not the memory impairment per se that drives them to place their loved one in a nursing home, so much as the agitation, aggression and even violence that demented patients frequ
RESEARCH NEWS 1998-08-20 Research News Stress and glucocorticoids (hormones produced in response to stress) are known to impair the acquisition and storage of new information. But stress also hinders the ability to recall memories, according to a study published by Benno Roozenda
RESEARCH NEWS 1998-08-20 Research News It has been theorized that cell membranes contain stable regions consisting of glycolipids and cholesterol. They are called detergent-insoluble glycolipid-enriched membrane domains (DIGs), or, more picturesquely, "rafts." These raf
RESEARCH NEWS 1998-08-14 Research News Transcription factors of the nuclear factor-kB/rel (NF-kB) family may be important in cell survival by regulating unidentified, antiapoptotic genes. One such gene that protects cells from apoptosis induced by Fas or tumor necrosis factor typ
RESEARCH NEWS 1998-08-14 Research News Acetylcholine has different effects on the excitability of different neuronal types, according to work by Xiang, et al, published in today's Science. The researchers examined two subtypes of interneurons in layer V of rat visual cortex.
RESEARCH NEWS 1998-08-14 Research News Maybe it is time to give up steak in order to live longer—at least if you are a fruit fly. According to a study published today in Science, a diet of sugar keeps flies in a metabolic "waiting mode," in which both reproduction and d
RESEARCH NEWS 1998-08-13 Research News An enzyme in Caenorhabditis elegans affects the rate at which the dainty worms age, by modulating the cellular response to oxidative stress. In today's Nature, Naoaki Ishii and his colleagues at the Tokai University School of Medicine,
COMMENT As a quick comment regarding Luc Buee's summary of Dr. Lindsay Farrer's talk on the genetics of AD and chromosome 12 in the Genetics I session of the Sixth Int. Conference on AD in Amsterdam, Dr. Buee reports that Dr. Farrer's genetic linka
COMMENT Dr. Lukiw does not mention that Dr. Peggy Vance reported that she replicated our significant genetic association of A2M and AD using the same A2M polymorphism (exon 18 deletion) in the same AD families (NIMH AD family set N = ~350) that we used and with t
COMMENT Dear Dr. Kosik, It was an honor that our work, presented at the Sixth International Conference on AD, was described in your briefing about presenilin-binding proteins. Similarly to your team and the identification of the catenins as possible modulators of
CONFERENCE COVERAGE 1998-07-22 Conference Coverage Because presenilin was discovered in positional cloning experiments involving large familial Alzheimer's disease kindreds, there were no previous data concerning its biological function. As a result, many groups have used a variet
CONFERENCE COVERAGE 1998-07-22 Conference Coverage Note: This article was revised on 10 August, 1998, to accommodate some factual corrections. See also R. Tanzi's comment, appended below. 22 July 1998. A study published last year by Margaret Pericak-Vance et al. (JAMA 1997;278) re
CONFERENCE COVERAGE 1998-07-22 Conference Coverage Yamaguchi (Abstract 1245) presented his theory that very diffuse plaques within nondemented individuals are cleared by astrocytic phagocytosis. He showed many examples of very diffuse Aβ-positive staining within the brains of 40-50 yea
CONFERENCE COVERAGE 1998-07-22 Conference Coverage A new epidemic of "mad tau disease" swept Amsterdam at the workshop on Hereditary Fronto-Temporal Dementia and Pick's disease. Fronto-temporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) has been linked t
CONFERENCE COVERAGE 1998-07-22 Conference Coverage While a number of drug companies have been pumping big bucks into creating novel molecules capable of inhibiting formation of Aβ fibrils, along comes Alan Snow and his colleagues at the University of Washington and his Seattle-based co
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