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COMMENT Reply by Dennis Selkoe Dear John: In response to your News and Views in the 8 April issue of Nature, I thought it would be helpful to indicate several points about your comments regarding the role of presenilins in APP processing with which my colleagues
RESEARCH NEWS 1999-04-09 Research News Three-dimensional images of enzymes at work in cells? This is the promise of a new advance in microscopy called fluorescence lifetime imaging microscopy (FLIM). Philippe Bastiaens and Anthony Squire at the Imperial Cancer Research Fund in Lo
RESEARCH NEWS 1999-04-05 Research News Fred Van Leeuwen and his colleagues reported last year that some neurons in Alzheimer's patients contain mutant RNA coding for APP and ubiquitin, despite the fact that the DNA from which the RNA had been transcribed was not mutated. By
RESEARCH NEWS 1999-04-01 Research News β-catenin, a protein that regulates transcription, has drawn attention in Alzheimer's research because it interacts with PS1 and PS2. It was also recently found that AD patients with the PS1 mutation have markedly reduced β-catenin in t
WEBINAR 1999-03-24 Paul Coleman, with Carl Cotman, Mark A. Smith, and George Perry, led this live discussion on 24 March 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 24 March 1
RESEARCH NEWS 1999-03-22 Research News It has long been assumed that the reason Alzheimer patients tend to get lost is because of memory failure and confusion. But a new study appearing in tomorow’s issue of Neurology suggests that impaired processing of visual information may co
RESEARCH NEWS 1999-03-19 Research News Researchers in the U.K. have created conditions inside a test tube in which human prion protein can flip back and forth between normal forms and abnormal forms associated with neurodegenerative disease. In its normal form, prion protein is r
RESEARCH NEWS 1999-03-18 Research News Ever since the ApoE4 allele was identified as a risk factor in late-onset Alzheimer's, researchers have speculated that ApoE interacts with β-amyloid. Several years ago, Kelly Bales and colleagues at Lilly Research Laboratories demonstr
INTERVIEWS 1999-03-15 Interviews ARF: What is the primary hypothesis that guides your laboratory? JH: Overall the theme of the lab is to use genetics to find what causes disease and to model the disease in cells and animals. With respect to AD, we believe that that approach ha
RESEARCH NEWS 1999-03-15 Research News The University of California, San Diego, Alzheimer's Disease Cooperative Study Center is launching a $22 million study to determine whether medical intervention in individuals with mild cognitive impairment (MCI), characterized primaril
RESEARCH NEWS 1999-02-26 Research News In the mid-1980s, Finnish researchers reported that 68 percent of heart attack patients and 50 percent of those with coronary heart disease had antibodies to the bacterium Chlamydia pneumoniae, as compared to 17 percent of healthy controls.
RESEARCH NEWS 1999-02-25 Research News Scientists at Sandia National Laboratories and M.I.T. have created the first computer simulation that successfully models how protein misfolding can occur. Protein misfolding is theorized to turn normally benign proteins into toxic aggregate
RESEARCH NEWS 1999-02-24 Research News Neurons are highly polarized cells, with certain proteins within them clearly restricted to specific regions of the plasma membrane. Yet they lack any obvious barriers to free protein diffusion that could explain this asymmetric distribution
RESEARCH NEWS 1999-02-22 Research News Several years ago, Karen Hsiao and colleagues at the University of Minnesota reported that mice containing an FAD mutant form of the human amyloid precursor protein (APP) are impaired in their ability to learn. These mice, however, do not ex
RESEARCH NEWS 1999-01-29 Research News The E4 gene variant of apolipoprotein E (ApoE) confers an increased risk of developing Alzheimer’s disease, but the mechanisms by which it does so are not understood. ApoE plays a role in transporting fatty molecules to cell membranes, and m
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