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340325 RESULTS

Notice of Informational Webinar: Implementation Research for Multi-morbidity Management in the Context of Non-communicable Diseases in Low and Middle-Income Countries and US Tribal Populations (R01 Clinical Trial Optional; R61/R33 Clinical Trial Required) (NOT-TW-24-011)

GRANT Friday, November 1, 2024- 3:15pm National Institutes of Health Tuesday, November 12, 2024 at 9:00 a.m. EST. Tuesday, November 12, 2024 at 3:00 p.m. EST. Both sessions will cover the same information. https://grants.nih.gov/grants/guide/notice-files/NOT-TW

Douglas Galasko on Amyloid Plaques Turn More Toxic as They Age

COMMENT This study elegantly places a timetable on plaque formation in a transgenic mouse model (AppNL-F) selected to develop amyloid pathology relatively slowly, using stable isotope labeling, mass spectrometry, advanced microscopy and spatial transcriptomic ana

Mapt knockout rat (Cy23)

RESEARCH MODELS Summary These tau knockout rats were created through transcription activator-like effector nuclease (TALEN)-mediated targeting of exon 2 of the rat Mapt gene (Ayers, Lopez et al., 2024). Tau protein was undetectable in the brains of Cy23 rats by western b

Tg12099 rat

RESEARCH MODELS Summary Tg12099 rats overexpress the 0N4R isoform of human tau with the P301S mutation linked to frontotemporal dementia. The MAPT transgene is driven by the rat Prnp promoter. Homozygous rats develop tau pathology, including neurofibrillary tangles, and

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