PAPER Russell JK, Conley AC, Wilson JE, Newhouse PA
SEARCH RESULTS
340325 RESULTS
NINDS Sustainable Transformation of Institutional Research Rigor (STIRR) Program (RC2- Clinical Trial Not Allowed) (RFA-NS-25-019)
GRANT Friday, November 1, 2024- 5:00pm National Institute of Neurological Disorders and Stroke Application budgets need to reflect the actual needs of the proposed project; however, it is anticipated that most awards will be between $150,000-$800,000 direct cos
Translational Neural Devices (R61/R33- Clinical Trial Optional) (PAR-25-053)
GRANT Friday, November 1, 2024- 4:30pm National Institute of Neurological Disorders and Stroke Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-053.html 29 Jan 2027
Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) (PAR-25-122)
GRANT Friday, November 1, 2024- 4:30pm National Institutes of Health Application budgets are limited to $100,000 in direct costs (excluding subcontract F&A) for one year and need to reflect the actual needs of the proposed project. Multiple due dates; see a
Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33- Clinical Trial Optional) (PAR-25-024)
GRANT Friday, November 1, 2024- 4:15pm National Institute of Neurological Disorders and Stroke Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-024.html 08 Jan 2028
Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed) (PAR-24-265)
GRANT Friday, November 1, 2024- 3:45pm National Institutes of Health Applications will be accepted that request a single, commercially available instrument or an integrated instrumentation system. The minimum award is $50,000. There is no upper limit on the cos
Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed) (PAR-24-268)
GRANT Friday, November 1, 2024- 3:45pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-24-268.html 28 Jan 2027
High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed) (PAR-24-264)
GRANT Friday, November 1, 2024- 3:30pm National Institutes of Health Applications will be accepted that request a single, commercially available instrument or an integrated instrumentation system. The minimum award is $750,001. There is no upper limit on the co
Notice of Informational Webinar: Implementation Research for Multi-morbidity Management in the Context of Non-communicable Diseases in Low and Middle-Income Countries and US Tribal Populations (R01 Clinical Trial Optional; R61/R33 Clinical Trial Required) (NOT-TW-24-011)
GRANT Friday, November 1, 2024- 3:15pm National Institutes of Health Tuesday, November 12, 2024 at 9:00 a.m. EST. Tuesday, November 12, 2024 at 3:00 p.m. EST. Both sessions will cover the same information. https://grants.nih.gov/grants/guide/notice-files/NOT-TW
Douglas Galasko on Amyloid Plaques Turn More Toxic as They Age
COMMENT This study elegantly places a timetable on plaque formation in a transgenic mouse model (AppNL-F) selected to develop amyloid pathology relatively slowly, using stable isotope labeling, mass spectrometry, advanced microscopy and spatial transcriptomic ana
PAPER Walker KA, An Y, Moghekar A, Moaddel R, Duggan MR, Peng Z, Tian Q, Pilling LC, Drouin SM, Espeland MA, Rapp SR, Hayden KM, Shadyab AH, Casanova R, Thambisetty M, Rapp PR, Kapogiannis D, Ferrucci L, Resnick SM
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience.
Mol Neurodegener. 2024 Oct 31;19(1):81. PubMed.Mapt knockout rat (Cy23)
RESEARCH MODELS Summary These tau knockout rats were created through transcription activator-like effector nuclease (TALEN)-mediated targeting of exon 2 of the rat Mapt gene (Ayers, Lopez et al., 2024). Tau protein was undetectable in the brains of Cy23 rats by western b
Tg12099 rat
RESEARCH MODELS Summary Tg12099 rats overexpress the 0N4R isoform of human tau with the P301S mutation linked to frontotemporal dementia. The MAPT transgene is driven by the rat Prnp promoter. Homozygous rats develop tau pathology, including neurofibrillary tangles, and
Melissa Murray, Baayla D.C. Boon on Amyloid Plaques Turn More Toxic as They Age
COMMENT This study investigates Aβ plaque pathology through a new mass spectrometry imaging method combined with isotope labeling (iSILK) in an Aβ knock-in mouse model (AppNL-F), and couples the plaque age with spatial transcriptomics. This approach enables the s
Santiago Sole-Domenech on A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, Seeding Plaque
COMMENT Kaji et al. propose that fibrillar ApoE—likely forming in microglia lysosomes after internalization and delipidation of the lipid carriers—promotes aggregation of Aβ. The authors preaggregated HFIP Aβ by incubating a solution in PBS for 48 hours at 37°C,
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