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Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease.
Nat Aging. 2025 Mar 10; Epub 2025 Mar 10 PubMed.PAPER Tang M, Rong D, Gao X, Lu G, Tang H, Wang P, Shao NY, Xia D, Feng XH, He WF, Chen W, Lu JH, Liu W, Shen HM
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Insulin resistance in Alzheimer's disease: signalling mechanisms and therapeutics strategies.
Inflammopharmacology. 2025 Mar 10; Epub 2025 Mar 10 PubMed.PAPER Qaisar R, Karim A, Iqbal MS, Alkahtani SA, Ahmad F
Associations of plasma Neurofilament light chain with sarcopenia and physical capacity in patients with Alzheimer's diseases.
Acta Neurol Belg. 2025 Mar 11; Epub 2025 Mar 11 PubMed.Robert Mach on A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.
COMMENT I congratulate the authors for trying to develop an alternative strategy to imaging reactive oxygen and reactive nitrogen species (ROS/RNS) in vivo with PET. Our group developed the radiotracer, [18F]ROStrace, and we have conducted PET imaging studies to
PAPER Gallagher E, Li S, Lee H, Xu H, Lee VMY, Mach RH, McManus MJ
Noninvasive Detection of Oxidative Stress in a Mouse Model of 4R Tauopathy via Positron Emission Tomography with [18F]ROStrace
Int. J. Mol. Sci. 2025 . International Journal of Molecular SciencesPierre Tariot on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients
COMMENT This strikes me as a thoughtful and rigorous effort to improve our understanding of the apparent increased risk of having a diagnosis of AD in women than men, the reasons for which are not fully elucidated. The authors make a compelling case that women ex
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THERAPEUTICS Inhibikase Therapeutics, Inc. IkT-148009 Small Molecule alpha-synuclein Other Between February 2021 and January 2023, Inhibikase ran a Phase 1 single- and multiple-ascending-dose trial. The study enrolled 108 participants, and tested nine single doses fro
COYA 302
THERAPEUTICS Coya Therapeutics IL2 plus Abatacept Combination Other Inflammation In October 2021, an investigator-initiated, open-label study of COYA 302 began at the Houston Methodist Research Institute. The study planned to enroll 10 people with ALS, treat them ever
Giulia Albertini
VIB/KU LeuvenBelgium
PAPER Liou JJ, Li J, Berardinelli J, Jin H, Santini T, Noh J, Farhat N, Wu M, Aizenstein HJ, Mettenburg JM, Yong WH, Head E, Ikonomovic MD, Ibrahim TS, Kofler JK, Alzheimer Biomarker Consortium—Down Syndrome
Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer's disease and related neurodegenerative pathologies using 7T postmortem MRI.
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Growth-associated protein 43 is associated with faster functional decline among amyloid-positive individuals with objectively defined subtle cognitive decline and mild cognitive impairment.
Neuropsychology. 2025 Mar;39(3):248-258. PubMed.PAPER Kubinski S, Claus L, Schüning T, Zeug A, Kalmbach N, Staege S, Gschwendtberger T, Petri S, Wegner F, Claus P, Hensel N
Aggregates associated with amyotrophic lateral sclerosis sequester the actin-binding protein profilin 2.
Hum Mol Genet. 2025 Mar 10; Epub 2025 Mar 10 PubMed.PAPER Jiang Y, Jin J, Piao Y, Yin Y, Tang L, Guan Q, Gao Y, Feng T, Wang Z
A simple and effective screening strategy for early multiple system atrophy diagnosis and α-Synuclein forms in erythrocytes.
Front Aging Neurosci. 2025;17:1533504. Epub 2025 Feb 21 PubMed.Current Filters
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