Martin Ingelsson, Dag Sehlin on Double Whammy: APP Uppsala Deletion Ups Aβ and Its Aggregation Propensity

COMMENT We appreciate the insightful comment by Drs. Ezzat and Espay and are grateful that our colleagues noticed an incorrect statement with respect to the MS-based levels of Aβwt1-42, which were indeed lower in mutation carriers as compared to control subjects.

Alzheimer's Disease vs Control: Aβ38 (CSF)

BIOMARKER META ANALYSIS 0.920807786243006 0.85332027485511 0.993632759223626-2.12444191030089 0.0336332086231168 0.780916763617068 0.0174521128326773 Biomarker Comparison Reference:  Biom Comparison: 1690066_1690071 Effect Metric:  0.817187218663974 Lower CI:  0.614198269979088

Control vs Alzheimer's Disease: Aβ38 (CSF)

BIOMARKER META ANALYSIS 1.08600298014432 1.00640804232476 1.17189293336525 2.12444191030089 0.0336332086231168 0.780916763617068 0.0174521128326773 Biomarker Comparison Reference:  Biom Comparison: 1690071_1690066 Effect Metric:  1.22370979031575 Lower CI:  0.919740812144861 Upp

Dementia with Lewy Bodies vs Alzheimer's Disease: Aβ38 (CSF)

BIOMARKER META ANALYSIS 0.714080625729401 0.508804910113144 1.00217417306115-1.9474048722161 0.051486214407545 0.850127262945386 0.07445646234272001 Biomarker Comparison Reference:  Biom Comparison: 1688861_1688856 Effect Metric:  0.471781221994652 Lower CI:  0.339297317850347 U

Frontotemporal Dementia vs Alzheimer's Disease: Aβ38 (CSF)

BIOMARKER META ANALYSIS 0.78371831774872 0.671658195782634 0.914474662010465-3.09561849035528 0.00196402883257577 0.82598138809943 0.0396157854630288 Biomarker Comparison Reference:  Biom Comparison: 1688851_1688841 Effect Metric:  0.633160087276012 Lower CI:  0.535168351646127

MCI-AD vs MCI-Stable: Aβ38 (CSF)

BIOMARKER META ANALYSIS 1.12695137424435 1.02899201804784 1.23423639604187 2.57594602982164 0.009996624843615539 Biomarker Comparison Reference:  Biom Comparison: 1690111_1690116 Effect Metric:  1.07912816902444 Lower CI:  0.939903593097691 Upper CI:  1.23897558614931 LN Effect

Normal Pressure Hydrocephalus vs Alzheimer's Disease: Aβ38 (CSF)

BIOMARKER META ANALYSIS 0.557031834015799 0.501134020827956 0.6191646370253689-10.8449380136028 2.10778696099039E-27 Biomarker Comparison Reference:  Biom Comparison: 1698556_1698546 Effect Metric:  0.49581737064644 Lower CI:  0.34539938509004 Upper CI:  0.711740887930836 LN Eff

Parkinson's Disease vs Alzheimer's Disease: Aβ38 (CSF)

BIOMARKER META ANALYSIS 0.873621107413619 0.732457289367498 1.04199091250448-1.50252617117738 0.132961274215716 0.841097016886201 0.0187419021578997 Biomarker Comparison Reference:  Biom Comparison: 1690076_1690066 Effect Metric:  0.941640112731367 Lower CI:  0.725496777750076 U

Vascular Dementia vs Alzheimer's Disease: Aβ38 (CSF)

BIOMARKER META ANALYSIS 0.8031058780547921 0.738607562981869 0.8732364569383519-5.1332983498799 2.84708045343256E-7 Biomarker Comparison Reference:  Biom Comparison: 1698601_1698571 Effect Metric:  0.82503308757113 Lower CI:  0.72391794431763 Upper CI:  0.940271754457979 LN Effe

Alzheimer's Disease vs Control: Aβ40 (CSF)

BIOMARKER META ANALYSIS 0.912651921394621 0.873392421331075 0.953676158943397-4.07422692212433 4.61674494104907E-5 0.794519478430349 0.0177527070492966 Biomarker Comparison Reference:  Biom Comparison: 1688891_1688896 Effect Metric:  0.831690493580475 Lower CI:  0.74265364619742

Alzheimer's Disease vs Control: Aβ40 (Plasma and Serum)

BIOMARKER META ANALYSIS 1.04367088485779 0.98452880873195 1.10636571143386 1.43610518303523 0.150972413483811 0.940286421598893 0.0364350044181435 Biomarker Comparison Reference:  Biom Comparison: 1701866_1701861 Effect Metric:  0.948800351563389 Lower CI:  0.788192003012009 Upp

Cerebral Amyloid Angiopathy vs Alzheimer's Disease: Aβ40 (CSF)

BIOMARKER META ANALYSIS 0.7526990469149391 0.658906549639496 0.85984250048301-4.18387481887572 2.86581959226097E-5 Biomarker Comparison Reference:  Biom Comparison: 1688921_1688916 Effect Metric:  0.784291238779145 Lower CI:  0.65965219732758 Upper CI:  0.932480403639533 LN Effe

Control vs Alzheimer's Disease: Aβ40 (CSF)

BIOMARKER META ANALYSIS 1.09796355688869 1.05009985485448 1.14800889332825 4.10960005487301 3.96344960096382E-5 0.797759426100901 0.0179451782450618 Biomarker Comparison Reference:  Biom Comparison: 1688896_1688891 Effect Metric:  1.20237036219441 Lower CI:  1.07365028271421 Upp

Control vs Alzheimer's Disease: Aβ40 (Plasma and Serum)

BIOMARKER META ANALYSIS 0.952123531287593 0.8973336184433131 1.01025883818352-1.62243223858822 0.104710831004262 0.9419817525005419 0.0362481470017101 Biomarker Comparison Reference:  Biom Comparison: 1701861_1701866 Effect Metric:  1.05396250997615 Lower CI:  0.875552818323512

Depression vs Alzheimer's Disease: Aβ40 (CSF)

BIOMARKER META ANALYSIS 0.910769154682942 0.818864773974715 1.0129883217415-1.72218434645275 0.0850361295510548 0.0133569765485147 9.05880864868033E-5 Biomarker Comparison Reference:  Biom Comparison: 1688901_1688891 Effect Metric:  0.985953579459574 Lower CI:  0.817428785282398