Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H, Blennow K, Karydas AM, Teunissen CE, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Rabinovici GD, Dage JL, Rojas JC, Boxer AL, Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators. Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration. Nat Med. 2020 Mar;26(3):387-397. Epub 2020 Mar 2 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ40
(Plasma)		 AD
(35)		 245.9 ± 43
pg/mL		 SIMOA;
Neurology -plex A;
Quanterix		 McKhann et al., 2011
Aβ40
(Plasma)		 CTRL-
CNC
(38)		 248.4 ± 52
pg/mL		 SIMOA;
Neurology -plex A;
Quanterix
Aβ40
(Plasma)		 FTD-
bvFTD
(12)		 231.3 ± 40
pg/mL		 SIMOA;
Neurology -plex A;
Quanterix		 Rascovsky et al., 2011
Aβ40
(Plasma)		 PSP
(27)		 252.6 ± 50
pg/mL		 SIMOA;
Neurology -plex A;
Quanterix
Aβ42
(Plasma)		 AD
(35)		 19.7 ± 7
pg/mL		 SIMOA;
Neurology -plex A;
Quanterix		 McKhann et al., 2011
Aβ42
(Plasma)		 CTRL-
CNC
(38)		 21.5 ± 6
pg/mL		 SIMOA;
Neurology -plex A;
Quanterix
Aβ42
(Plasma)		 FTD-
bvFTD
(12)		 23.3 ± 6
pg/mL		 SIMOA;
Neurology -plex A;
Quanterix		 Rascovsky et al., 2011
Aβ42
(Plasma)		 PSP
(27)		 23.5 ± 8
pg/mL		 SIMOA;
Neurology -plex A;
Quanterix
NFL
(Plasma)		 AD
(26)		 20.7 ± 14
pg/mL		 SIMOA;
Other/Not Specified;
Quanterix		 McKhann et al., 2011
NFL
(Plasma)		 CBS
(32)		 42.6 ± 27
pg/mL		 SIMOA;
Other/Not Specified;
Quanterix
NFL
(Plasma)		 CTRL-
CNC
(28)		 15.2 ± 8
pg/mL		 SIMOA;
Other/Not Specified;
Quanterix
NFL
(Plasma)		 FTD-
bvFTD
(40)		 30.3 ± 33
pg/mL		 SIMOA;
Other/Not Specified;
Quanterix		 Rascovsky et al., 2011
NFL
(Plasma)		 PSP
(45)		 33.8 ± 26
pg/mL		 SIMOA;
Other/Not Specified;
Quanterix
tau-p181
(CSF)		 AD
(16)		 45.8 ± 31
pg/mL		 xMAP;
INNO-BIA AlzBio3;
Fujirebio		 McKhann et al., 2011
tau-p181
(CSF)		 CBS
(11)		 22.2 ± 11
pg/mL		 xMAP;
INNO-BIA AlzBio3;
Fujirebio
tau-p181
(CSF)		 CTRL-
CNC
(20)		 24.4 ± 12
pg/mL		 xMAP;
INNO-BIA AlzBio3;
Fujirebio
tau-p181
(Plasma)		 AD
(56)		 8.4 ± 4
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
Lilly/Meso Scale Discovery		 McKhann et al., 2011
tau-p181
(Plasma)		 CBS
(39)		 2.5 ± 3
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
Lilly/Meso Scale Discovery
tau-p181
(Plasma)		 CTRL-
CNC
(69)		 2.4 ± 3
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
Lilly/Meso Scale Discovery
tau-p181
(Plasma)		 FTD-
bvFTD
(50)		 1.9 ± 2
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
Lilly/Meso Scale Discovery		 Rascovsky et al., 2011
tau-p181
(Plasma)		 FTD-
nfvPPA
(27)		 2.7 ± 3
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
Lilly/Meso Scale Discovery		 Gorno-Tempini et al., 2011
tau-p181
(Plasma)		 FTD-
svPPA
(26)		 2.8 ± 4
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
Lilly/Meso Scale Discovery
tau-p181
(Plasma)		 PSP
(48)		 2.4 ± 3
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
Lilly/Meso Scale Discovery

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This paper appears in the following:

News

  1. A Phospho-Tau Plasma Assay for Alzheimer’s?
  2. New Assay, New Cohorts—Plasma p-Tau181 Looks Even Better
  3. Plasma Aβ Test Wins Approval—Are p-Tau Tests Far Behind?
  4. Where to Now, Phospho-Tau?

AlzBiomarker

  1. AD vs CTRL : Aβ40 (Plasma and Serum)
  2. CTRL vs AD : Aβ40 (Plasma and Serum)
  3. FTD vs AD : Aβ40 (Plasma and Serum)
  4. PSP vs AD : Aβ40 (Plasma and Serum)
  5. AD vs CTRL : Aβ42 (Plasma and Serum)
  6. CTRL vs AD : Aβ42 (Plasma and Serum)
  7. FTD vs AD : Aβ42 (Plasma and Serum)
  8. PSP vs AD : Aβ42 (Plasma and Serum)
  9. AD vs CTRL : NFL (Plasma and Serum)
  10. CBS vs AD : NFL (Plasma and Serum)
  11. CTRL vs AD : NFL (Plasma and Serum)
  12. FTD vs AD : NFL (Plasma and Serum)
  13. PSP vs AD : NFL (Plasma and Serum)
  14. AD vs CTRL : tau-p181 (CSF)
  15. AD vs CTRL : tau-p181 (Plasma and Serum)
  16. CBS vs AD : tau-p181 (CSF)
  17. CBS vs AD : tau-p181 (Plasma and Serum)
  18. CTRL vs AD : tau-p181 (CSF)
  19. CTRL vs AD : tau-p181 (Plasma and Serum)
  20. FTD vs AD : tau-p181 (Plasma and Serum)
  21. PSP vs AD : tau-p181 (Plasma and Serum)