Liquid Phase Transition: A Deluge of Data Points to Multiple Regulators
Transportins, methylation, and RNA all regulate LLPS and the behavior of pathogenic RNA-binding proteins.
ALL NEWS
6566 RESULTS
Sort By:
- Most Recent
- Most Commented
Loss of Soothing Lipids in AD Brain Furthers Microglial Mayhem
In an AD mouse model, a deficit in specialized mediators prevented microglia from tempering inflammation and clearing Aβ. Time to learn about resolvins?
Japanese ADNI Data Parallel North American ADNI, Encouraging Global Trials
The two datasets reveal almost identical cognitive decline in prodromal AD, the stage targeted by secondary prevention trials.
Cholesterol Greases the Aβ Aggregation Machine
Exposure to lipid membranes embedded with cholesterol accelerate Aβ fibril formation by up to 20-fold.
Study Finds Sex Influences CSF Tau Levels in ApoE4 Carriers
ApoE4 raises CSF tau more in women than in men, suggesting sex may influence the risk of neurodegeneration, especially in amyloid-positive E4 carriers.
Liver Tox Ends Janssen BACE Program
The company has halted all trials of atabecestat.
Exercise Program Fails to Ease Dementia
Contradicting current opinion, a randomized trial made people stronger but, if anything, left their mental function weaker. What gives?
Hanging in There: Another BACE Inhibitor Still Safe in Phase 2
In 18-month data from a small trial, elenbecestat appeared well-tolerated, with no signs of liver toxicity. PET imaging indicated a drop in brain amyloid, while clinical endpoints trended toward a slowing of cognitive decline.
Antisense Oligonucleotides Turn Down the Aβ Spigot
In mice, antisense oligonucleotides that splice out more than half of the Aβ peptide drive down its levels in the brain.
Synaptojanin 1 Gene Affects Age of Onset in Familial AD, Memory in Mice
Overexpression of synaptojanin 1 leads to hippocampal place cell dysfunction in mice. Could it contribute to memory problems in AD?
Blood Pressure Affects Dementia Risk Only in People Under 60
A large epidemiological study better defines the risk from hypertension. This may sharpen recommendations for prevention.
α-Synuclein Antibody Appears Safe, Reaches Brain
Roche and Prothena publish Phase 1b results for their antibody PRX002/RG7935.
Nano-size Quantum Dots Bust Up Synuclein Pathology
Tiny yet mighty, small carbon structures glom onto and dissolve α-synuclein fibrils, neutralizing their toxicity in mouse models of Parkinson’s disease.
CRISPR Gene Editing May Not Be so Precise After All
Researchers found large deletions, inversions, or insertions in about one-fifth of edited cells, suggesting caution for therapeutic uses of the technology.
Jumping Genes Rampant in Tau Flies
By loosening their chromatin straitjackets, and reining in their RNA watchdogs, tau unleashes transposable elements into the genome.
Current Filters
No filters selected