Another Side of APP: Does α-Secretase Processing Drive Fragile X Syndrome?
Soluble APPα ramps up early in a mouse model of Fragile X Syndrome, and may promote symptoms of the disease. Blocking the peptide’s production could be a treatment strategy.
ALL NEWS
6566 RESULTS
Sort By:
- Most Recent
- Most Commented
C9ORF72, Sporadic ALS Transcriptomes Now Available
Researchers have published RNA expression and processing data for the cerebellum and frontal cortex, and find that C9ORF72-based ALS and sporadic disease differ greatly.
New C9ORF72 Antibodies Find Isoforms in Different Cellular Locations
The protein normally comes in long and short isoforms, which hang out in the cytoplasm and on the nuclear envelope, respectively.
Second Trial of Diaphragm Pacing for ALS Shuts Down
A third trial continues in the United States
PINK1 Can Act Alone to Destroy Mitochondria, But Parkin Helps
Scientists flesh out how PINK1 and parkin instigate mitophagy and what role the ALS genes optineuron and TBK1 play in the process.
Does Peripheral Immune Activity Tame Alzheimer’s Disease?
Relieving systemic immune suppression facilitates the entry of immune cells into the brain and slows amyloid accumulation in a mouse model of aggressive Aβ pathology, scientists claim.
Extra Weight in Midlife Hastens Onset of Alzheimer’s Disease
For every unit increase in body mass index in midlife, the age at onset of AD dropped by more than half a year. Amyloid PET links the effect to AD pathology.
Magnet Test Finds Cortex Overexcitable in All ALS
Researchers using transcranial magnetic stimulation report that C9ORF72-based ALS, like other forms, leads to motor cortex hyperexcitability.
GATA4 and Cellular Senescence Said to Stoke ‘Inflammaging’
GATA4 transcription factor connects selective autophagy to pro-inflammatory state of cells harboring DNA damage. Researchers propose the pathway may play a role in age-related disease.
Atrial Fibrillation in Middle Age Ups Dementia Risk
In a large population study, middle-aged people who developed atrial fibrillation were about twice as likely as their peers to succumb to dementia over the next 20 years.
Alzheimer’s Risk Genes Interact in Immune Cells
A CD33 variant associated with Alzheimer’s boosts levels of wild-type TREM2, hinting that these risk factors could share a common mechanism.
Young ApoE4 Carriers Wander Off the ‘Grid’ — Early Predictor of Alzheimer’s?
Grid cells in the entorhinal cortex help with spatial navigation, and the cells’ function falters in young people at risk for AD.
Aβ Immunotherapy Revs Up Neurons in Mice—What About in People?
Researchers propose the same phenomenon explains poor clinical trial results.
Could Untranslated Regions of RNA Help Control Gene Expression?
High expression of RNA-untranslated regions occurs in consistent patterns and seems to correlate with low protein expression, researchers report.
A Secretase Complex Built for Two
Do α- and γ-secretase band together to cleave substrates such as the amyloid precursor protein?
Current Filters
No filters selected