Results of Ladostigil Trial Published
The Phase 2 study missed its primary endpoint. While fewer developed dementia in the treatment group, the effect was not statistically significant. People on drug had less brain atrophy than those on placebo.
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Tiny Brain Structure Plays Big Role in Memory
New data strengthen the idea that a healthy locus coeruleus keeps memory sharp into old age.
Hello Mitochondriomics: Tagging Method Identifies Different Subtypes
The organelles express unique sets of proteins depending on their environment. Astrocyte mitochondria process lipids better than those in neurons.
PET Identifies Tangles Decades after a Single Traumatic Brain Injury
The pattern varied from person to person, depending on the site of injury, in contrast to the stereotyped distribution of tau tangles seen in Alzheimer’s disease.
Can Induced Neurons Identify Early Signs of Neurodegeneration?
In patient-derived neurons, tau mutations scupper lysosomes and SORLA shunts APP through different types of endosomes.
Islands of Tau Coat and Protect Cytoskeleton
The protein forms cohesive rafts along microtubules, protecting them from digestion and regulating movement of molecular motors.
Are Microglia Plaque Factories?
Eliminating microglia in a mouse model of amyloidosis nearly abolished parenchymal plaques, but led to a huge buildup of amyloid in cerebral blood vessels.
Smart Homes Open Doors to Insights into Aging, Dementia
Passive monitoring of old people in their everyday lives is starting to generate new indicators for cognitive impairment.
Technology Brings Dementia Detection to the Home
Smartphones and gamified apps move cognitive testing from the lab into the real world. But keeping people engaged remains a problem. Is passive monitoring the answer?
Raw Deal: Lose Ataxin, Gain BACE
Loss of ataxin-1 intensifies BACE1 expression, Alzheimer’s pathogenesis. Is that how ataxin GWAS variants increase AD risk?
In Alzheimer’s, More TREM2 Is Good for You
Longitudinal ADNI data tie higher sTREM2 in CSF to slower cognitive decline, reinforcing the idea that TREM2 activity protects the brain from AD pathology.
Healthy Lifestyle Hedges Dementia Risk, but Not if Genetic Risk Runs High
Older people who lived healthy lifestyles had a third lower risk of dementia than their unhealthy peers, but only if their genetic risk for the disease was low.
Nixing Complement Protein Protects Neurons in Tauopathy Model
In a tauopathy model, knocking out C3 spared synapses and neurons. In an amyloidosis model, deleting C3 preserved dendritic spines, but exacerbated plaque growth.
Blood Pressure: How Low to Prevent Dementia—and When?
Hypertension in people as young as the mid-30s can predict late-life cerebrovascular disease and brain shrinkage. Intensive reduction of blood pressure can prevent the damage, but not when given in late life.
Spatial Transcriptomics Uncovers Coordinated Cell Responses to Amyloid
In vicinity of plaques, astrocytes and glia change gene expression in concert.
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