Colombian Cohort Delivers Data on Blood NfL
In 2,144 Colombian ADAD family members, plasma NfL in gene carriers rises as early as two decades before their symptoms start.
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Crenezumab Update: Baseline Data from Colombian Prevention Trial
At AAIC, researchers presented baseline data from an ongoing, five-year study asking whether the anti-Aβ antibody crenezumab can forestall cognitive decline in autosomal-dominant Alzheimer’s disease.
Colleagues Mourn Loss of Rahul Desikan, Age 41, to ALS
Desikan pioneered advances in neuroimaging and neurogenetics, and was known for his passion and collaborative spirit.
As DIAN Wraps Up Anti-Aβ Drug Arms, it Sprouts Tau, Primary Prevention Arms
The DIAN Trials Unit is nearing the end of its first two secondary prevention trials. It has begun a cognitive run-in period for its next trial, of a tau-based drug, and for a primary prevention study in people as young as 18.
ASOs: Wave of the Future in Alzheimer’s Therapeutics?
As the Alzheimer’s field suffers smackdowns in trials of small molecules and antibodies, antisense oligonucleotides are quietly coming along—and looking safe so far.
Genetics Propels DIAN Toward Therapies
Nearly 30 years after the first Alzheimer’s gene discoveries, genetics once again drives recruitment, scientific progress, and therapy development in the Dominantly Inherited Alzheimer’s Network.
DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community
A brother’s survival guilt, a journalist tracing her mutation to Lebanon, a student freezing her eggs ahead of a primary prevention trial—DIAN family members are stirring their growing community to act against Alzheimer’s disease.
High and Low Hemoglobin Levels Tied to Alzheimer’s
Too much or too little serum hemoglobin increases risk for Alzheimer’s and other dementias by 20 percent or more.
Ribosomal Protein Spurs Faulty Translation of Nucleotide Repeats
RPS25 helps translate repetitive snippets of RNA that are associated with neurodegenerative diseases. Knocking it down reduces protein aggregates and cell death.
2019 DIAD Family Conference: Mutation, Participation, Innovation.
DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community Genetics Propels DIAN Toward Therapies ASOs: Wave of the Future in Alzheimer’s Therapeutics? As DIAN Wraps Up Anti-Aβ Drug Arms, it Sprouts Tau, Primary Prevention Arms On July 13,
Human Microglia Make Themselves at Home in Mouse Brain
Analysis of a chimeric mouse shows that the cells express the same genes they do in the human brain, survey their environment, and respond to injuries and amyloid.
AbbVie’s Tau Antibody Flops in Progressive Supranuclear Palsy
The company halted its Phase 2 trial of ABBV-8E12 due to lack of efficacy.
Anatomy News Flash: Brain Drains Lymphatic Fluid Through Its Base
In mice, the back of the brain, near the neck, contains lymphatic vessels that are specialized to take up cerebrospinal fluid and deliver it to cervical lymph nodes.
Physical Activity May Shield the Brain from the Onslaught of Aβ
Middle-aged people who exercise more are less likely to become amyloid-positive. In late life, people with brain amyloid who exercise declined more slowly and had less brain shrinkage over the following years.
New PET Staging Scheme for Amyloid?
Longitudinal data identifies four stages of amyloid plaque buildup, with the earliest deposits appearing in the precuneus and posterior cingulate.
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