Mysterious RNA Circles Crop up in Alzheimer’s Brain
The circular transcripts correlate with AD pathology and dementia severity, suggesting potential roles in pathogenesis or as biomarkers.
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Amyloid—It’s Not Whether, but for How Long You’ve Had It
A new study argues that the duration of a person’s amyloid positivity predicts whether they’ll develop tau accumulation and cognitive decline.
MRI and Machine Learning Depict Brain Aging in Health, Disease
From more than 45,000 MRI scans, a typical pattern of brain aging emerges. Brains “age” faster in people who have a neurological disorder.
Anti-Agitation Drug Comes Up Short in Phase 3
Negative findings for AVP-786 belie positive findings from a separate Phase 3 trial announced earlier this year.
NIH Funds Translational Research Centers to Accelerate AD Drug Discovery
$73 million to transform big data into open-access targets and drugs for testing in clinical trials.
Frontal Metabolic Patterns Mark Behavioral Subtype of AD
Hypometabolism in the frontal cortex and in the anterior default mode network distinguish the behavioral variant of AD from typical AD.
'Runner Plasma' Jogs Neurogenesis, Quells Neuroinflammation in Mice
Sedentary mice infused with the plasma of active ones had more newborn neurons in the brain and less neuroinflammation. Exercising upped plasma clusterin in mice and in humans.
LRRK2 Mutation Fires Up Immune Response, Harms Brain
The G2019S variant that boosts Parkinson’s risk helps mice survive infection, but raises α-synuclein in the brain and increases neuronal death.
Mitochondrial Jetsam Spurs Neurodegeneration
Spewed by stressed microglia, fragments of the organelles provoke mitochondrial fission in other cells, causing astrogliosis and neuronal loss.
Mutant Tau Stiffens Axon Cytoskeleton Near Soma
In neurons derived from FTD patients, morphological changes at the base of the axon render them hyperexcitable.
In Mice and Men, Prostate Drug Reportedly Treats Parkinson’s Disease
In animal models and patient-derived neurons, terazosin elevated ATP and warded off neurodegeneration. Men who take the drug to control prostate hyperplasia are less likely to get PD, or have milder symptoms.
Phase 3 Trial Suggests Pimavanserin Assuages Psychosis in Dementia
The study halted early when the primary endpoint was met, but an unusual trial design and lack of detailed data leave questions unanswered.
Chris Dobson, Master of Protein Folding Research, Dies at 69
A chemist at the University of Cambridge, Dobson developed equations that described the kinetics of protein aggregation in diseases such as Alzheimer’s.
Among AD Mutations, Only ApoE4 Seems to Hobble Microglia
In induced human microglia, the E4 allele profoundly affected their health and cellular responses, while familial Alzheimer’s mutations had little effect.
End of the BACE Inhibitors? Elenbecestat Trials Halted Amid Safety Concerns
Biogen and Eisai announced the discontinuation of the Phase 3 program. Elenbecestat was the only remaining BACE inhibitor being tested for AD.
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