Single-Cell Expression Atlas Charts Changes in Alzheimer’s Entorhinal Cortex
Specific patterns of expression defined distinct subtypes of neurons, astrocytes, oligodendrocytes, and microglia in this early affected brain region.
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The Human Brain Hosts a Menagerie of Microglia
Brain biopsy tissue reveals that their transcriptomes shift by location, age, and disease.
Microglia Inflammasome Stokes Tau Phosphorylation, Tangles
In a mouse tauopathy model, knocking out the NLRP3 inflammasome prevented toxic tau from forming.
Minocycline Does Not Work in Mild Alzheimer’s Disease
Based on preclinical data, researchers gave this antibiotic a shot in a two-year clinical trial. It did nothing to slow cognitive decline.
Cell-Specific Enhancer Atlas Centers AD Risk in Microglia. Again.
Cataloguing enhancer-promoter interactions in the four major cell types of the brain, researchers found that Alzheimer’s risk variants predominantly appeared in microglial enhancers.
Scientists Discover a Common Distress Signal in the Blood-Brain Barrier
The same endothelial cell response is found in various models of brain disease.
Dipeptide Repeat Proteins Don’t Directly Block Nuclear Transport
New data suggest that while peptides translated from an expansion in the C9ORF72 gene are toxic, they don’t directly interfere with nucleocytoplasmic transport.
Already in Mid-30s, Poor Vascular Health Means Small Brain at 70
No link found with amyloid deposition.
Acetaminophen Derivative Tempers Microglia, Spurs Plaque Clearance
DAPPD suppressed neuroinflammation and preserved cognition in mouse models of amyloidosis, suggesting potential for treating Alzheimer’s disease.
Older Retired Soccer Players Prone to Neurodegeneration
While former professional soccer players have less risk for heart disease and cancer than the general population, they are five times more likely to die with a neurodegenerative disease in old age.
China Approves Seaweed Sugar as First New Alzheimer’s Drug in 17 Years
GV-971, an oligosaccharide derived from marine kelp, was approved to treat AD in China. Preclinical studies suggest the drug soothes neuroinflammation by balancing the gut microbiome.
Can an ApoE Mutation Halt Alzheimer’s Disease?
The rare ApoE3 Christchurch variant prevented tau tangles, neurodegeneration, and cognitive decline in a woman’s brain for decades, despite massive amyloid buildup from a familial presenilin AD mutation.
Deep Sleep Makes Waves for CSF
Slow-wave sleep brings on coordinated oscillations in blood flow, which in turn are coupled to waves of cerebrospinal fluid. The data point to a mechanism linking deep sleep to the flow of CSF.
ApoE4 and Tau in Alzheimer’s: Worse Than We Thought? Especially in Women
Imaging studies suggest that ApoE4 carriers may be more susceptible to the effects of tangles, particularly if they are women.
Right Turn: Aβ Fibril Structure from Alzheimer’s Brain Reveals Surprising Twist
The first ever cryoEM structures of Aβ fibrils extracted from AD tissue look quite different than prior structures of fibrils generated in vitro. For starters, they are right-hand twisted, not left-hand.
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