Society for Neuroscience Annual Meeting: DIGs—a Site of Aβ?
Kawarabayashi (319.10) presented compelling data for a time-dependent accumulation of Aβ in the detergent-insoluble glycolipid enriched membrane domains (DIGs) of Tg2576 mouse brain...
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Society for Neuroscience Annual Meeting: The TGN—Where It's Happening?
In an exhaustive study, Iwata (240.1) presented evidence that the trans Golgi network was the major site of Aβ42 production in both neural and non-neural cells...
Society for Neuroscience Annual Meeting: TACE, TAPI, and ADAM10
The mechanisms of regulated α-secretase cleavage were thoroughly examined in two excellent companion posters from Virginia Lee’s lab...
Society for Neuroscience Annual Meeting: Endocrepsin is BACE
At times the scene around this poster (240.11) was more like a football scrimmage or a rugby scrum than the normally genteel atmosphere associated with a scientific event...
Soc for Neuroscience Ann Mtg: Proteasome Inhibition Boosts Aβ
Janet Johnston (240.16) presented a detailed study of the effect of proteasome and prolendopeptidase (PEP) inhibitors on Aβ production by SH SY 5Y human neuroblastoma cells stably transfected with SPA4CT (C99)...
Society for Neuroscience Annual Meeting: APP Binds to Fibrillar Aβ
Treatment of human cerebovascular smooth muscle (HCSM) cells with Aβ1-42 or AβQ22 (a mutant associated with hereditary cerebral hemorrhage with amyloidosis-Dutch type) leads to the formation of ...
Society for Neuroscience Annual Meeting: Evidence for Additional Genetic Risk Factors for AD
Papassotiropoulos (1201) began his presentation by reviewing the evidence for a role of cathepsin D, an aspartyl protease, in AD. Previous work has implicated catD as a secretase in the cleavage of APP...
Society for Neuroscience Annual Meeting: Imaging Amyloid Plaques in the Living Mouse
One of the limitations in studying the pathogenic role of amyloid plaque deposition is the fact that conventional methods allow microscopic analysis only of postmortem tissue, which can provide...
Society for Neuroscience Annual Meeting: β-Secretase Further Confirmed
Sukanto Sinha, departing from his abstract (122.1), described the purification and partial characterization of a novel 501 amino acid long aspartyl protease, The data were entirely consistent with the...
Society for Neuroscience Annual Meeting: Another APP Secretase?
Just when it appeared as though the mechanisms of the proteolytic processing of APP were finally becoming apparent, Andreas Weidemann presented an elegant study demonstrating the existence of a different processing event...
Soc for Neuroscience Ann Mtg: One γ-Secretase, Two Different Activities?
Using difluoroketone peptidomimetics previously shown to reversibly inhibit γ-secretase activity in CHO cells, Michael Wolfe reported that increasing the bulkiness of the P1 substituent...
Society for Neuroscience Annual Meeting: Caspase-mediate Production of Aβ
In testing the hypothesis that unscheduled cell death may alter APP processing, Andrea Le Blanc (122.4) provided compelling evidence that caspase 6 can directly cleave APP...
Soc for Neuroscience Ann Mtg: APP and Intracellular Aβ Balance Critical
Recent studies have demonstrated that wild-type APP can protect against p53 mediated apoptosis, whereas FAD mutant APP (FADAPP) cannot. N3 rat neuroblastoma cells which are deficient in APP were transfected with wtAPP or FADAPP...
Society for Neuroscience Annual Meeting: α1-Antichymotrypsin
Yamin (122.9) presented evidence that the zinc metalloproteinase EC 3.4.24.15 (E24.15) plays a role in neuronal mediated degradation of Aβ...
Society for Neuroscience Annual Meeting: Making the Right Mouse Model?
Several groups have reported a lack of phenotype in α-synuclein (α-S) transgenic mice, but it appears Lennart Mucke (122.10) has got it right...
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