Making Do Without NMDA Receptors
Memory deficits due to NMDA receptor loss in the hippocampus can be overcome by enriched environments, according to a report from Joe Tsien and his Princeton colleagues in the March issue of Nature Neuroscience...
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α-Synuclein Transgenic Mice Show Parkinson-like Pathology
Several neurodegenerative diseases, including Alzheimer's, Parkinson's and Lewy body disease, are characterized by abnormal neuronal inclusions of α-synuclein, one of the brain's synaptic proteins...
How Does Calorie Restriction Extend Life?
One part of the answer to this question may involve the yeast nuclear protein Sir2, according to a study in tommorow's issue of Nature. Leonard Guarente, Shin-ichiro Imai and their coworkers at MIT say the protein is regulated by NAD...
Unmasking Gene Mutations: One in the Hand Is Better
Genetic tests based on polymerase chain reactions often fail to detect mutations when both a mutant and a wildtype gene exist in the genome. The key to "unmasking" the mutant allele...
Death Takes a Different Cell Route
A caspase protease in the endoplasmic reticulum (ER) may have a hand in cell death in Alzheimer's, according to a report in the January 6 issue of Nature. The caspases appear to play critical roles in various apoptotic mechanisms...
Prion Parts Can Infect Other Proteins
The essential "prion-determining" portion of a prion protein can be removed and fused to a wholly separate protein, creating a new prion with the essential prion qualities of state changing and heritability...
Early Transcriptional Changes in a Trinucleotide Repeat Disorder
Some of the earliest cellular changes of the trinucleotide repeat disorder spinocerebellar ataxia type 1 (SCA1) appear only one day after the mutant gene that causes the disorder begins to be expressed...
Latest Techniques in Targeting Alzheimer's
A transcript of Bio Online's panel discussion on January 12 is now available...
Why Is an Enterovirus Hiding out in ALS Spinal Cords?
As with many neurodegenerative diseases, viruses have waxed and waned in popularity as possible causative agents in amyotrophic lateral sclerosis (ALS, known as Lou Gehrig's disease in the U.S.)...
NGF Gene Therapy Trial Begins
The green light has been given for Mark Tuszynski and his colleagues from the University of California, San Diego, the Salk Institute, and UC Davis to start a Phase I (safety) trial of nerve growth factor (NGF) gene therapy for early onset Alzheimer's...
Aβ Primes an Inflammatory Pump
A paper in today's Science offers a candidate pathway for inflammatory processes in Alzheimer's disease; the pathway uses the CD40 receptor on microglia and is upregulated by Aβ...
CREB Is Linked to Cell Survival
Today's issue of Science brings evidence that CREB (cAMP response element binding protein) is an essential element in the cell survival pathway of nerve growth factor (NGF)...
Toward a Unified Prion Theory
A report in today's Nature shows that prion forms found in apparently anomalous prion diseases are likely to represent the common final path to neurodegeneration in all the spongiform encephalopathies...
Enzyme Essential to Brain Development Found to Hyperphosphorylate Tau, Kill Neurons
A newcomer has joined the ranks of suspects implicated in early Alzheimer's disease. In tomorrow's Nature, Li-Huei Tsai of Harvard Medical School and her colleagues report that the protein p25 deregulates the kinase cdk5...
Depression Symptoms May Reflect Alzheimer's Pathology
A study in this month's Neurology suggests that depression symptoms seen in early Alzheimer's are related to AD pathology, rather than being a response to memory loss and other Alzheimer's symptoms...
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