Stem Cells Restore Some Spinal Cord Function
In the political arena, there is almost daily rhetoric about the use of fetal and embryonic tissue in research. Meanwhile, in the laboratory, researchers continue to produce results certain to...
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Gathering at the β-Secretase Corral
The October report in Science by Vassar and colleagues idetifying β-secretase has now been followed up by three more reports this month identifying the BACE enzyme...
More Than One Path to Nitric Oxide Damage
A report in this month's Nature Medicine adds detail, and complexity, to the role of nitric oxide in the neurodegeneration of Parkinson's disease...
Society for Neuroscience Annual Meeting 1999
Society for Neuroscience Annual Meeting: β-Secretase Further Confirmed Society for Neuroscience Annual Meeting: Another APP Secretase? Society for Neuroscience Annual Meeting: Imaging Amyloid Plaques in the Living Mouse Soc for Neuroscience Ann Mtg: One γ
Society for Neuroscience Annual Meeting, Miami: Tau Update
Toward a neurofibrillary degeneration animal model, Michael Vitek's group (317.1) reported on their tau knockouts. Homozygous mice demonstrated the lack of tau...
Fetal Cell Transplants Do Work in Parkinson's
Ten years after a fetal cell transplant, a Parkinson's patient's graft is still delivering dopamine to postsynaptic cells, according to a study appearing in the December issue of Nature Neuroscience...
Society for Neuroscience Annual Meeting: Which Aβ Species Is the Culprit?
Dean Hartley (12.5) presented data on the deleterious effects of "protofibrillar" Aβ on neurons. Several other groups have reported that amyloid protofibrils of one sort of another...
Society for Neuroscience Annual Meeting: ApoE Affects Pattern of Amyloid Deposition in Tg Mice
Irizarry and collaborators (626.5) provided intriguing new results from transgenic mouse lines expressing human APP (the PDAPP mice) in the presence or absence of endogenous mouse ApoE...
Presenilin-1 Interferes with Protein Folding
A report in the current Nature Cell Biology describes a mechanism by which presenilin-1 (PS-1) mutations can interfere with protein folding. Kazunori Imaizumi of Osaka University and colleagues suggest that...
Society for Neuroscience Annual Meeting: α-Synuclein: A Review
Hashimoto, Masliah and colleagues (27.14) reported that cytochrome C stimulates α-synuclein aggregration in vitro and that cytochrome C can be observed in Lewy bodies, in postmortem brain tissue...
Society for Neuroscience Annual Meeting: Presenilins: An Overview
Research on presenilins presented at this year's meeting centered around two major questions: 1) What is the role of presenilins in Aβ production and APP processing, and 2) what are the other biological actions of presenilins?...
Society for Neuroscience Annual Meeting: Be Wise—Immunize!
In the relatively short time allotted, Dale Schenk (519.5) managed to describe most of the data from his group’s recent Nature paper (Nature 1999;400:173-177), and a little more...
Society for Neuroscience Annual Meeting: A Sniff of Aβ
Chronic mucosal administration of certain proteins is known to decrease organ-specific autoimmune processes in several autoimmune models, including those affecting the CNS...
Soc for Neuroscience Annual Meeting: Lipoproteins Reduce Clearance of Aβ
Using exquisite human primary cortical cultures containing neurons, astrocytes, and microglia, Nadeau (319.1) demonstrated that addition of VLDLs or HDLs increased media levels of both Aβ40 and Aβ42...
Soc for Neuroscience Ann Mtg: Reduced Cholesterol Levels Inhibit Aβ
Using primary hippocampal neurons transfected with APP by means of the Semliki-forest-virus expression system, Christine Bergmann (319.2) demonstrated that lovastatin (which inhibits de novo cholesterol synthesis)...
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