Society for Neuroscience Annual Meeting: Caspase-mediate Production of Aβ
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In testing the hypothesis that unscheduled cell death may alter APP processing, Andrea Le Blanc (122.4) provided compelling evidence that caspase 6 can directly cleave APP and cause an increase in Aβ levels in serum deprived human primary neurons. She is currently examining the p10 active fragment of caspase 6 in AD brain and non-AD age matched controls.—Dominic Walsh
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