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Creatine, increasingly popular as a dietary and exercise supplement, has shown the ability to counteract laboratory models of amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's disease...
The true identity of γ-secretase, the enzyme that frees amyloid-β from its membrane-bound precursor, is one of the holy grails in the search for the cause of Alzheimer's disease...
The cysteine protease calpain cleaves the cdk5 regulator p35, releasing a 25KD fragment that accumulates in the brains of people with Alzheimer’s disease. What’s more, Aβ42 is among the factors...
According to a report in today's Science, a productive approach to combating the spongiform encephalopathies such as the transmissible "variant" Creutzfeldt-Jacob disease may be to attack cells in the spleen where...
The DNA sequence of human chromosome 21 will be published electronically today in Nature (and in print on 18 May). This achievement, by an international consortium of 62 scientists reveals that chromosome 21...
The neuronal peptide α-synuclein is an important constituent of the Lewy bodies, pathological hallmarks of the Lewy body variant of Alzheimer's disease, as well as of Parkinson's and several other neurodegenerative diseases...
Chris Weihl Interviews Benjamin Wolozin MD, PHD
Many researchers believe that the amyloid-β peptide is a culprit in the neurodegenerative process of Alzheimer's disease. Indeed, they can marshal good evidence that the fibrillar form of Aβ kills neurons in a petri dish...
Some of the attention focused on amyloid-β may have to be diverted to yet another peptide product of amyloid precursor protein (APP). Daniel Lu, Edward Koo and colleagues report in the April issue of Nature Medicine that...
Inhibiting cell death proteases, or caspases, can prolong the life of mice with the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), Robert Friedlander...
Chris Weihl Interviews Marsel Mesulam
Researchers from the Medical University of Lubeck in Germany say that they have failed to replicate the tantalizing evidence from a study published two years ago that found <em>Chlamydia</em> in almost all the Alzheimer's brains examined...
Conventional wisdom has it that each member of the large G protein-coupled receptor (GPCR) family pairs up exclusively with another of its own kind. But a new study in tomorrow's Science reports that two different GPCRs...
A central controversy in the Alzheimer's field has been the issue of whether amyloid plaques, comprising primarily Aβ peptide, correlate with the severity of dementia. Inconsistent findings on this point have fueled arguments...
Mel Feany and Welcome Bender of Harvard Medical School have succeeded in creating a transgenic <em>Drosophila melanogaster</em> model of Parkinson's, and surprisingly, have demonstrated that the flies feature...
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