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Neural stem cells have been heralded as a potential therapy to rebuild injured and diseased brain tissue, but to achieve that vision, researchers must decipher the molecular signals that direct the cells to migrate through the brain...
A two-gene therapy strategy prevents the death of dopamine neurons and preserves their function, according to a study by Jorg Schulz and colleagues at the University of Tubingen in Germany...
Researchers announced a step forward in the rational design of drugs to inhibit β-secretase with the publication in tomorrow's Science of the crystal structure of the enzyme locked in a complex with a novel inhibitor...
A nasally administered vaccine of amyloid-β (Aβ) can significantly reduce the Aβ burden in the brains of transgenic mouse models of Alzheimer's disease, report Howard Weiner, Dennis Selkoe, and their Harvard colleagues...
A feat that has eluded researchers for some time—the creation of an animal model of human mitochondrial DNA (mtDNA) diseases—has finally been accomplished. Japanese researchers report that they have created mutant mice with a large-scale mtDNA deletion...
The prion protein, so interesting to researchers of neurodegenerative disease for its novel capacity to cause disease through a change of conformation—and to transmit disease to other cells and organisms through its altered conformation—may have...
Through a nice piece of protein chemistry work, Yu and colleagues from Peter St. George Hyslop’s laboratory have shown that a novel protein, named nicastrin, associates with preseniln 1 and presenilin 2...
The intracellular protein Fyn—a suspect in the formation of neurofibrillary tangles because of its associations with tau protein—has now popped up in conjunction with prion diseases...
From today's Science: Researchers have built a microarray designed to study the interactions of thousands of proteins simultaneously, helping to uncover their function...
The possibility of using stem cells from the brain to grow neural tissues has advanced a key step now that British scientists have coaxed certain nerve cells backwards in their development process to the stem cell stage...
High-throughput screening for proteins is now possible, according to report in this month's Nature Biotechnology. Researchers in England have designed an array, similar to DNA microarrays, that can screen for more than 18,000 proteins at once...
The ε4 variant of the apolipoprotein-E (ApoE) gene has been shown to confer increased risk for Alzheimer's disease. Gary Small, Susan Bookheimer, and colleagues report that carriers of the ε4 allele need to exert their brains more...
A number of inherited neurodegenerative disorders (e.g., Huntingtons's disease and spinal and bulbar muscular atrophy) have been traced to the abnormal repetition of CAG sequences in the coding for particular proteins...
A protein previously identified as a transporter of inorganic phosphate also transports glutamate into synaptic vesicles, according to a paper in today's Science...
Epidemiological studies have hinted strongly that nonsteroidal anti-inflammatory drugs (NSAIDs) might delay the progression of Alzheimer's disease. In the August 1 issue of the Journal of Neuroscience...
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