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As with many neurodegenerative diseases, viruses have waxed and waned in popularity as possible causative agents in amyotrophic lateral sclerosis (ALS, known as Lou Gehrig's disease in the U.S.)...
The green light has been given for Mark Tuszynski and his colleagues from the University of California, San Diego, the Salk Institute, and UC Davis to start a Phase I (safety) trial of nerve growth factor (NGF) gene therapy for early onset Alzheimer's...
A paper in today's Science offers a candidate pathway for inflammatory processes in Alzheimer's disease; the pathway uses the CD40 receptor on microglia and is upregulated by Aβ...
Today's issue of Science brings evidence that CREB (cAMP response element binding protein) is an essential element in the cell survival pathway of nerve growth factor (NGF)...
A report in today's Nature shows that prion forms found in apparently anomalous prion diseases are likely to represent the common final path to neurodegeneration in all the spongiform encephalopathies...
A newcomer has joined the ranks of suspects implicated in early Alzheimer's disease. In tomorrow's Nature, Li-Huei Tsai of Harvard Medical School and her colleagues report that the protein p25 deregulates the kinase cdk5...
A study in this month's Neurology suggests that depression symptoms seen in early Alzheimer's are related to AD pathology, rather than being a response to memory loss and other Alzheimer's symptoms...
In the political arena, there is almost daily rhetoric about the use of fetal and embryonic tissue in research. Meanwhile, in the laboratory, researchers continue to produce results certain to...
The October report in Science by Vassar and colleagues idetifying β-secretase has now been followed up by three more reports this month identifying the BACE enzyme...
A report in this month's Nature Medicine adds detail, and complexity, to the role of nitric oxide in the neurodegeneration of Parkinson's disease...
Society for Neuroscience Annual Meeting: β-Secretase Further Confirmed Society for Neuroscience Annual Meeting: Another APP Secretase? Society for Neuroscience Annual Meeting: Imaging Amyloid Plaques in the Living Mouse Soc for Neuroscience Ann Mtg: One γ
Toward a neurofibrillary degeneration animal model, Michael Vitek's group (317.1) reported on their tau knockouts. Homozygous mice demonstrated the lack of tau...
Ten years after a fetal cell transplant, a Parkinson's patient's graft is still delivering dopamine to postsynaptic cells, according to a study appearing in the December issue of Nature Neuroscience...
Dean Hartley (12.5) presented data on the deleterious effects of "protofibrillar" Aβ on neurons. Several other groups have reported that amyloid protofibrils of one sort of another...
Irizarry and collaborators (626.5) provided intriguing new results from transgenic mouse lines expressing human APP (the PDAPP mice) in the presence or absence of endogenous mouse ApoE...
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