World Alzheimer Conference 2000: Presenilin Roundup
Presenilins and Lewy body pathology. Lippa et al (173) used α-synuclein immunoreactivity to determine the frequency of Lewy body (LB) occurrence in familial Alzheimer's disease...
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World Alzheimer Conference 2000: Synuclein Update
Increasing attention has focused on the role of synucleins in neurodegeneration. α-synuclein was originally cloned by Richard Scheller from rat brain (1). Subsequently...
Imaging Plaques in AD Patients
Joseph F. Poduslo and colleagues at Mayo Clinic report in the August issue of Nature Biotechnology (pp. 868-872) on a technique for imaging Aβ deposits in living brain...
NFTs in Mice
Mice carrying the P301 mutation in tau, which causes human frontotemporal dementia, develop neurofibrillary pathology with features mimicking those of human tauopathies...
Chris Weihl Interviews Richard Mayeux
Chris Weihl Interviews Richard Mayeux
World Alzheimer Conference 2000: Evolving Brain Abnormalities in AD
This symposium (held 10 July) covered the gamut of age-related evolution of brain function in AD from behavioral studies emphasizing mild cognitive impairment (MCI) through microscopic structure...
World Alzheimer Conference 2000: Array Technologies in Alzheimer's Research
The relative paucity of presentations utilizing array technologies to study alterations of gene expression in Alzheimer's disease indicates that these powerful technologies are yet to be fully utilized in the study of AD...
World Alzheimer Conference 2000: Presentations on Mild Cognitive Impairment
Mild cognitive impairment (MCI) has been defined as a clinical entity whose characteristics were reviewed by Ron Petersen. Persons with MCI have memory impairment beyond what would be expected for age, yet they are not demented...
World Alzheimer Conference 2000: Nearing Home BACE?
There were a number of oral and poster presentations at the World Alzheimer Congress 2000 relating to BACE biology...
World Alzheimer Conference 2000: Amyloid Is Necessary and Sufficient to Cause Dementia
The scientific highlight of the Prof. Henry Wisniewski memorial symposium (12 July) was an informative lecture about familial British dementia (FBD)...
World Alzheimer Conference 2000: Presenilin's γ-Secretase Activity
Almost 12% (152) of the 1307 abstracts presented at the 7th International Conference on Alzheimer’s Disease and related disorders made reference to presenilin (PS)...
World Alzheimer Conference 2000: Pin1 Binds Both Tau and APP
One of the great unsolved mysteries of Alzheimer's disease is the link between the disease's two major lesions: β amyloid plaques and tau tangles...
World Alzheimer Conference 2000: Hot Topics in AD
Several late-breaking, dramatic results were presented at this final symposium of the World Alzheimer Congress 2000...
World Alzheimer Conference 2000: Hot Topics Symposium
Michael Hutton and colleagues from Mayo Laboratory, Jacksonville, revealed that double transgenics expressing the Swedish APP mutation and P301L tau also had NFTs and neuropathology...
World Alzheimer Conference 2000: Maybe Plaques Kill Neurons after All
Although there are many reports of neurotoxic effects of amyloid when applied to neurons in culture, the evidence for toxicity in vivo has been...
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