Patients Being Recruited for Phase I Growth Factor Trial
A Phase I clinical trial of growth factor gene therapy for Alzheimer's disease is currently in progress at the University of California, San Diego...
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Exelon Dose Revised
According to a "Dear Healthcare Provider" letter dated January 26 and posted this week on the Web site of the U.S. Food and Drug Administration, patients who take breaks in Exelon...
Neurogenin Suppresses Astrocyte Differentiation
Stem cell researchers know only too well that most adult neural precursor cells differentiate into astrocytes, not the coveted nerve cells. Even when stimulated by the addition of neuron-inducing growth factors...
AF102B (Cevimeline or Evoxac) Lowers CSF Aβ in Alzheimer Patients
A drug currently approved by the FDA for the treatment of dry mouth in Sjogren's syndrome (an autoimmune disease that affects excorine glands) has been shown to reduce levels of amyloid-β...
Neprilysin Steps out of the Shadows
The enzyme neprilysin—capable of degrading Aβ42 peptide—is a new player in the Alzheimer's disease mystery. Writing in Neuroscience Letters, Patrick McGeer's group at the University of British Columbia adds critical circumstantial evidence...
Study Finds Treatments for Agitation Are Inadequate
The drugs haloperidol or trazodone, or behavior management techniques (BMT), are commonly used to treat agitation in Alzheimer's patients...
Glia May Regulate Synaptic Formation and Transmission
Glial cells quietly play a much bigger role than ever imagined, according to an article in today's issue of Science. Ben Barres and colleagues at Stanford report that astrocytes exert a powerful influence on communication between neurons...
Part II: News Summary from American Society for Cell Biology Meeting
James Bamburg presented a poster (Abstract 2821) on the formation of cellular inclusions composed of actin-depolymerizing factor (ADF) and the cofilin family of proteins (collectively known as AC) and of their putative involvement in neurodegeneration...
American Society for Cell Biology: 40th Annual Meeting
News Summary from the 40th Annual Meeting of The American Society for Cell Biology Part II: News Summary from American Society for Cell Biology Meeting American Society for Cell Biology: 2000 Annual Meeting
GFAP Mutation in Alexander's Disease
The cause of Alexander's disease, a very rare, inherited CNS disorder, has been traced to the gene for glial fibrillary acidic protein (GFAP), according to a report published in this month's Nature Genetics...
Trio of Papers Report Chromosome 10 Linkage
Three independent studies published in the 22 December issue of Science reported that chromosome 10 probably harbors one or more genes that confer an increased susceptibility to late-onset Alzheimer's disease...
American College of Neuropsychopharmacology 2000 Annual Meeting
Symposium: Gene Expression Profiling of Alzheimer's Disease American College of Neuropsychopharmacology 2000 Annual Meeting
Symposium: Gene Expression Profiling of Alzheimer's Disease
At the Annual Meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico, the speakers discussed the sequence of changes in gene expression in the brain that may take place during the transition from normal...
Selegiline Does Not Increase Parkinson's Death Rate
The drug selegiline, thought to be neuroprotective, has been used to treat Parkinson's disease for the past 25 years, but a report a few years ago suggested that the drug could accelerate death in patients taking it...
New DNA Array Method Paves Way to "User's Manual" for Master Genes
In today's issue of Science, researchers at the Whitehead Institute and Corning Inc. describe a new microarray technique that can decipher the function of master switches in a cell by identifying the set of genes they control across the entire genome...
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