Antisense Oligonucleotides: Can They Take on ALS, SMA, Prions?
Data on ASOs, presented recently at the annual meeting of the American Academy of Neurology, depict RNA-based therapies as broadly on the rise in neurodegenerative diseases.
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American Academy of Neurology 2019 Annual Meeting
Antisense Oligonucleotides: Can They Take on ALS, SMA, Prions? Drug Reported to Help Alzheimer’s Patients Sleep Better American Academy of Neurology 2019 Annual Meeting
Neurogenesis Wanes in Alzheimer’s, Along With Cognition
Research on postmortem human brain strengthens the idea that an ebbing of neurogenesis may underlie cognitive decline.
Brain Conference Spotlights Transcriptomics, Therapeutic Strategies
New potential immunotherapies and insight into single-cell responses were highlights of a small meeting in Denmark.
Anti-Tau Antibody Looks Safe, Hits Target
Phase 1b data show that Biogen’s BIIB092 lowers N-terminal tau fragments in cerebrospinal fluid by more than 90 percent.
Mutant Tau Messes Up Connectivity of Newborn Neurons
In a mouse model of frontotemporal dementia, a trifecta of tau mutations hobbles newborn neurons in the dentate gyrus.
γ-Secretase Revisited—Could Selective Inhibitors Treat AD, Cancer Safely?
A compound that only blocks presenilin 1-containing secretases beat back leukemia in mice—without side effects caused by broad-spectrum inhibitors.
Study Strengthens Link between Hepatitis C Virus, Parkinson’s
In Taiwan, interferon treatment for chronic hepatitis C infection appears to have reduced the incidence of Parkinson’s disease.
Sliced by ApoE Genotype, Whole Exome Data Yield New AD Variants
One rare variant protects ApoE4 carriers, others put noncarriers at risk.
TADPOLE Challenge: Winners Forecast AD Symptoms
Using different techniques, contestants vied for the best way to tell which ADNI participants would develop clinical, cognitive, or imaging signs of Alzheimer’s disease.
Meet medRχiv: A New Preprint Server for Health Research
Today, the creators of bioRχiv launch a repository for preliminary medical research, including clinical trial data.
New Tool: Microglia-Specific Reporter Mice, With Choice of Colors
Two groups create mice for imaging and manipulation of microglia, leaving related cells untouched. The trick? Piggybacking on Tmem119 expression.
Gently Used: Can Recycled Microglia Receptors Prevent Plaque?
Through an endocytic process called LANDO, microglia clear β-amyloid and route their used Aβ receptors, including TREM2, back to the plasma membrane. Without it, aggregates pile up outside and form plaques.
TREM2, Microglia Dampen Dangerous Liaisons Between Aβ and Tau
At a joint Keystone symposia, researchers reported how microglia, via TREM2, compress plaques and rein in the pathogenic distortion of neurites into swollen stubs. Without TREM2, these damaged neuronal processes served as fertile ground for tau propagation.
Joint Keystone Symposia: Neurodegenerative Diseases: New Insights and Therapeutic Opportunities and Neural Environment in Disease: Glial Responses and Neuroinflammation
TREM2, Microglia Dampen Dangerous Liaisons Between Aβ and Tau Down to Sex? Boy and Girl Microglia Respond Differently Dopaminergic Neurons Conjured from Astrocytes Restore Motion In PD Model, α-Synuclein Spreads from Intestine to Brain Do Microglia Finish
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