CRISPR Suppresses BACE1 and Plaques in Mice
Deleting BACE1 with CRISPR nanocomplexes tempered Aβ pathology and boosted memory.
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In Year Three, GAP Trial Network Is Starting to Hum
With three trials and initiatives to boost recruitment, GAP-Net is gaining some traction in the field.
GAP-Net Site Optimization Conference 2019
In Year Three, GAP Trial Network Is Starting to Hum Getting to Go: GAP-Net Sets Sight on Faster Start Three years after the Global Alzheimer’s Platform (GAP) Foundation launched GAP-Net, a standing network of clinical trial sites optimized for Alzheimer’s
Getting to Go: GAP-Net Sets Sight on Faster Start
From central IRBs, certified raters, to local transport: Changes large and small are needed to ramp up drug testing in Alzheimer’s.
NIH Summit Sets Agenda for AD-Related Dementias
Among 20 focus areas, 47 research recommendations cover the gamut from basic science to health disparities.
Randall Bateman Wins Potamkin Prize
Award recognizes his contributions to basic and clinical research.
FDA Panel Rejects Neuronix Brain Stimulation Device
Experts said Phase 3 data did not prove the device could slow AD.
Results from IDEAS Study Published
A majority of amyloid PET scans led physicians to change how they managed a patient’s disease. The effect on later outcomes is yet to be come.
Resetting Brain Rhythms Gives Working Memory a Brief Boost
Transcranial, alternating electrical current restored neuronal synchrony in older people, rejuvenating working memory. For an hour or two.
Familial Alzheimer’s Mutations: Different Mechanisms, Same End Result
A fleet of patient-derived neurons show that while an APP mutation shifts where γ-secretase takes its first bite, PS1 mutations blunt the enzyme’s second cut. Eventually, all mutations drive up the Aβ42:40 ratio.
Amid Brexhaustion, U.K. DRI Marches On, Seeks Innovation Director
Institute to chart new translational research territory.
At AD/PD Conference, New Alzheimer’s Genes Reinforce Known Pathways
After years of grunt work on next-gen sequencing and expression analysis, geneticists are finally reaping results. The new genes underscore the role of known pathways and cell types in disease.
International Conference on Alzheimer's and Parkinson's Diseases 2019
At AD/PD Conference, New Alzheimer’s Genes Reinforce Known Pathways Expression, Expression, Expression—Time to Get on Board with eQTLs APP Upp: Mutation Nixes Six Amino Acids from Aβ, Spurs Aggregation Parsing How Alzheimer’s Genetic Risk Works Through Mi
Expression, Expression, Expression—Time to Get on Board with eQTLs
A tool of modern genetics, expression studies link GWAS hits to specific cell types, providing clues to pathogenesis. Microglia come up again and again.
APP Upp: Mutation Nixes Six Amino Acids from Aβ, Spurs Aggregation
Presented at AD/PD, the discovery by scientists in Uppsala is the first APP deletion found to cause Alzheimer’s disease. The same group found the Swedish and Arctic APP mutations.
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