Protein Folding 101—Unboiling the Egg
Today's Science contains a basic-science review relevant to anyone studying plaque or tangle formation, or the unfolded protein response in Alzheimer's or Parkinson's disease...
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Degeneration, Regeneration, Fertility—Variations on Nna Theme?
The loss of neurons associated with such diseases as Alzheimer's and Parkinson's have long been attributed to neural degeneration. But could this degeneration actually belie underlying problems in regeneration?...
Would the Real γ-Secretase Please Stand Up
The identity of γ-secretase, the aspartyl protease responsible for snipping amyloid-β (Aβ) from β-secretase-processed amyloid precursor protein (AβPP), has remained elusive for some time...
EU Committee Recommends Approval Of Memantine
The European Union's Committee of Proprietary Medicinal Products (CPMP) has recently recommended that the EU approve <a href="/therapeutics">memantine</a> for the treatment of moderately severe to severe Alzheimer's disease...
Want to Keep Your DNA in Good Repair? Then Eat Your Spinach!
Even as vitamin E appears to be losing some of its memory-saving appeal, the B vitamin folate (i.e. folic acid) is becoming the nutrient <em>du jour</em>. Besides helping to prevent birth defects, it probably reduces the risk of heart disease, stroke, and some cancers...
Down and In—the Location of Amyloid-β Does Matter
Though the roles of the Aβ peptide and AβPP in the pathology of Alzheimer's disease have been well studied, many questions remain to be answered, not least being cause and effect—are plaques the root or the result of the problem?...
It's Official: The First Human AD Vaccine Trial
Elan Corporation and American Home Products announced today what everyone already expected...
Follow Cholesterol, Find Link to Presenilins
An article in tomorrow's Journal of Neuroscience adds a few clues to the still-murky relationship between cholesterol and Alzheimer disease...
New Neurons in Old Brains Make New Contacts
Studies over the last few years have debunked the dogma that new neurons cannot grow in adult mammalian brains. In fact...
More Cases of Brain Inflammation in Vaccine Trial
The Washington Post reported last Friday that a dozen patients in the suspended trial of the Aβ vaccine AN-1792 have now fallen ill with cerebral inflammation...
Patients Sought for Nutritional Supplement Clinical Trial
The Memory Evaluation and Treatment Service at Burke Medical Research Institute in New York has started a therapeutic trial of a nutritional supplement—a "metabolic enhancer"...
Another Huntingtin Partner Points Toward Proteasome
Polyglutamine (poly Q) expansion in the huntingtin protein (htt) causes Huntington's disease (HD), yet it remains unclear clear how this expansion induces the cellular and neurological damage of the disease...
Add Mental Exercise to Potential AD Protection
Evidence is accumulating that certain activities are correlated with a reduced risk of Alzheimer's disease, though whether this relationship is one of cause and effect is still open to debate. Recent articles have demonstrated this link...
Adenovirus-Mediated Local Modification of Brain Genotype
In theory, genetic manipulation is the only permanent method of altering the biochemistry of somatic cells. In practice, the concept faces many hurdles, not least being a safe and accurate method of delivering the right gene to the right place...
Early-Stage Alternative Vaccine Reported: Better Antibody Response with Liposomes?
Just as immunotherapy for Alzheimer's disease has encountered its first problems in the clinic, new approaches are emerging in the research pipeline...
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