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Over the past decade, it has become clear that microorganisms are vastly more diverse and ubiquitous than our egocentric species ever thought possible. This has led some scientists to suspect that microbes may be causing human diseases...
Though considerable effort has been spent over the last few decades investigating the relationship between Alzheimer's disease and aluminum, the role of the transition metal remains controversial...
The case for using magnetic resonance imaging to monitor changes associated with memory loss or cognitive impairment was boosted by research published in last week's PNAS...
Scientists have been racing to develop simple, non-invasive, and accurate tools for the early diagnosis of Alzheimer's disease (AD). Recently, brain imaging has received a boost by the findings of Silverman et al...
Transgenic mice have become a staple in the study of basic biology and disease, including Alzheimer's. Even so, the method predominantly used today to create these animals remains technically difficult, costly, and impractical in other animal species...
P53 misregulation and cancer have become almost synonymous in the scientist's imagination. Mutations in this prominent tumor suppressor gene have been found in the majority of human cancers...
A study in last month's Neurology provides more evidence that people who engage in little leisure activity are at greater risk for developing Alzheimer's disease. The study, by Yaakov Stern et al. at Columbia University, New York, is noteworthy...
The question of how neurofibrillary tangles (NFTs) contribute to the profound loss of neurons in Alzheimer's disease remains unsettled in part because of a dearth of suitable animal models...
In 1999, Warrick et al. showed that the molecular chaperone Hsp70 could suppress neurodegeneration mediated by polyQ expansions in a protein associated with spinocerebellar ataxia...
Just in time to ponder this weighty question comes a short communication in tomorrow's Nature. Martin Carrier and colleagues at the William Harvey Research Institute in London report that polyphenols in red wines potently inhibit expression of the vasoconstrictor peptide endothelin-1...
The Science Fiction channel occasionally runs a marathon of "Twilight Zone:" Back-to-back episodes all day long, each one related to the other through novel scripts with interesting ideas that border on fantasy...
A study of the elderly in Sweden provides more evidence that people with a higher level of education are less likely to be diagnosed with Alzheimer's disease or other dementias...
In last Friday's Nature, Lawrence Goldstein of the University of California, San Diego, further advanced his claim that the amyloid-β precursor protein (AβPP) mediates fast, anterograde axonal transport by binding to the motor protein kinesin-1...
CNDR 2nd Annual Retreat: Welcome and Introduction CNDR 2nd Annual Retreat: Amyloid-binding Ligands as AD Therapies CNDR 2nd Annual Retreat: Gonadal Hormones Control β-Amyloid in Vivo CNDR 2nd Annual Retreat: Metal Complexing Agents as Therapies for AD CND
The discovery of newly born neurons in the adult primate neocortex caused a great stir two years ago, opening, as it seemed, one of the most promising avenues of research into replacing neurons destroyed by neurodegenerative disease...
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