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It has been known since Waller's description in 1850 that axons of damaged neurons degenerate on the distal side of the lesion. Wlds mice exhibit slow Wallerian degeneration, but while they are known to harbor an 85 kb tandem triplication...
Researchers from Bart de Strooper's lab at the Flanders Interuniversity Institute for Biotechnology, reported in the 20 November Neuron that telencephalin (TLN), a member of the intercellular adhesion molecule (ICAM) family, binds to presenilins 1 and 2...
Post-Conference News: Oligomers, Protofibrils, and Fibrils—They Are All Bad Post-Conference News: Fly-Fishing for γ-Secretase Function and Substrates Society for Neuroscience Annual Meeting 2001
A number of presentations at this year's Society for Neuroscience meeting provided new insight into the biology of presenilin. First, about its function. Deletion of the notch receptor in Drosophila produces a characteristic, hypomorphic phenotype...
Extensive data supporting a central role for Aβ in the genesis of Alzheimer's disease notwithstanding, the amyloid hypothesis has its weaknesses...
The debate over the etiology of Parkinson's disease (PD) has been spurred by an article in the November 14 Journal of the American Medical Association, in which the authors contend that genetics, not just environmental factors...
RNA profiling is increasingly being used in the study of Alzheimer's disease, but interpreting the pretty microarray patterns can be difficult. To name but one problem, individual neurons vary greatly in their degree of pathology...
One of the most coveted achievements AD researchers are striving for these days is to develop a biomarker that could, simply and inexpensively, detect if a person has early Alzheimer's disease...
For years, scientists have tried to create transgenic mice that form neurofibrillary tangles, one of the two pathological hallmarks of Alzheimer's disease. All attempts failed until last year...
In a preliminary but tantalizing finding, Chris Conrad and coworkers reported today that they have found a novel, small gene in an intron of the tau gene, and that this new gene has a single-nucleotide polymorphism...
A bold, but also much-criticized, experimental therapy for Parkinson's disease involves injecting dopaminergic, human embryonic neurons into a dopamine-depleted brain area of patients...
If you thought Parkinson's disease is simply a motor disorder, think again. In recent years, researchers have increasingly realized that the disease has a cognitive component as well...
The β-secretase enzyme BACE1 become an instant favorite among researchers interested in developing small-molecule drugs against Alzheimer's disease...
There are two principal ways by which the Aβ accumulation seen in the brains of people with AD can occur. One—overproduction by β- and γ-secretases...
On this second day of the conference, scientists gave an update on the current status of Aβ vaccination. Since researchers at Elan Pharmaceuticals in 1999 first demonstrated the basic principle to immunize...
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