6545 RESULTS
Sort By:
Though the successful development of DNA chip technology has facilitated the simultaneous measurement of thousands of mRNA transcripts in a single sample, the technology is presently incapable of distinguishing between alternatively spliced transcripts...
The old dogma that the brain and the immune system don't mix is crumbling. We now know that the CNS is not entirely privileged, and that immune cells do invade it under certain conditions. This realization...
The similarities between the γ-secretase-mediated processing of AβPP and the Notch receptor suggest that the AβPP intracellular domain (AICD), like its Notch counterpart, could play a role in signal transduction...
Everyone agrees: from plaques to tangles, Alzheimer's to Parkinson's, insoluble protein bodies are associated with neurodegeneration. This begs the obvious question...
Despite the recent setbacks in Elan's clinical trials, vaccines still have enormous potential as therapeutic agents for a variety of disorders. As reported last week at the American College of Cardiology's 51st annual scientific session in Atlanta...
Unlike AβPP, whose physiological function remains nebulous, the protein tau is widely thought to promote neurite extension by stabilizing microtubules...
The link between mild cognitive impairment and Alzheimer's disease pathology grows stronger with a study in this month's Annals of Neurology. Kathy Riley, David Snowdon, and William Markesbery of the University of Kentucky report a strong correlation...
Predicting who may get Alzheimer's disease still is an almost impossible exercise. Yet with several promising treatments looming on the horizon, early diagnosis is becoming increasingly desirable...
Several recent reports have tantalized us with the possibility that adult stem cells exist that can be reprogrammed to produce various tissue types, including neurons...
A report in the current issue of the Archives of Neurology suggests yet again that cholesterol has some link with Alzheimer's disease. Kristine Yaffe and colleagues at the University of California, San Francisco, and elsewhere...
Conference Coverage: IPSEN Foundation Ipsen Colloquium on Immunization against Alzheimer's and Other Neurodegenerative Diseases 2002
ARF Scientific Advisor David Holtzman, of Washington University, St. Louis, Missouri, sent us this report from the IPSEN Foundation conference "Immunization against Alzheimer's and other Neurodegenerative Diseases," held on 13 March in Paris, France...
A nonsteroidal antiinflammatory drug (NSAID) with nitric oxide-releasing capabilities dramatically reduced amyloid burden in a transgenic mouse model, according to a report in today's Journal of Neuroscience...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting motor neurons of the central nervous system. Though its biology is poorly understood, one controversial theory suggests that oxidative damage...
Anyone who has ever contemplated the devastating effects of a neurodegenerative disease like Alzheimer's disease has two disturbing questions embedded in the back of their mind—is it going to happen to me, and if so, when?...
No filters selected
