Using RNAi to Silence HIV—What about Alzheimer's?
For several years scientists have been using RNA interference, commonly known as RNAi, to post-transcriptionaly silence the expression of selected proteins...
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Dynamitin in Motor Neurons: Dynamite for ALS Research?
Disruption of an axonal transport system in transgenic mice leads to a late-onset, slowly progressive motor neuron disease reminiscent of human motor neuron diseases, such as ALS. A related paper shows this axonal transport system is necessary for synaptic stability in fruit flies.
Dopamine Renders α-Synuclein Toxic to Neurons
In tomorrow's Nature Medicine, Bruce Yankner at Children's Hospital in Boston offers up a partial explanation for one of the abiding questions in Parkinson's research: Why do neurons die in such a selective pattern?...
Run For Your Brain: Exercise Boosts Hippocampal Gene Expression, Neurogenesis
In a related story (see below), Carl Cotman and Nicole Berchtold of the University of California, Irvine, detail the effects of exercise on brain plasticity...
Keep It Up: Activity-Induced Neurogenesis in Hippocampus Not Just a Blip
In today's online edition of Annals of Neurology, researchers report that a form of neuroplasticity—namely the birth of new neurons in the brain's hippocampus—can be continuously stimulated by an active, challenging lifestyle throughout...
Presenting: A Not-Quite-Parkinson's Mouse Model
A transgenic mouse overexpressing a mutant human form of α-synuclein develops Lewy body inclusions that cause neurodegeneration and a severe movement disorder, according to report in yesterday's Neuron...
Wingless Pathway Helps Tauopathy Take Off
The microtubule-associated protein tau is the major component of the intracellular neurofibrillary tangles (NFT) found in patients with various neurodegenerative disorders, including Alzheimer's and frontotemporal dementia. Scientists know that hyperphosphorylation of tau is at the root of its pathology, but...
Zapping Amyloid with SAP Inhibitors
The idea of shrinking amyloid plaques by drawing Ab out of the brain and into the circulation, where it can be destroyed, lately has gained some acceptance...
Toward Zeptomole Proteomics in Cerebrospinal Fluid
In the post-genome era, the next big challenge lies in mapping the proteome of every cell type, a daunting task indeed. One obstacle will be to identify trace amounts of proteins in cell or tissue samples...
ARF Advisor to Receive National Medal of Science
Ann Graybiel of the Massachusetts Institute of Technology, a member of the Alzheimer Research Forum's scientific advisory board since 1999, is one of 15 scientists...
Sniff This: Therapeutic Peptides Through the Nose?
Peptides make lousy drugs, especially for the brain. When taken as a pill or by infusion, they either bounce off the blood-brain barrier, or get degraded within minutes...
Astrocytes May Hold Key to Adult Neurogenesis
The discovery that new functional neurons arise daily in adult brains has raised hopes that endogenous stem cells may be coaxed to replace neurons lost or damaged...
Synaptic Zinc Fingered As Critical In Plaque Formation
For some time, in vitro and human research has indicated that heavy metals such as zinc, copper, or iron, are critical for the aggregation of Aβ into plaques...
Transcriptional Activators Kidnapped by Huntingtin
It is well known that an expanded polyglutamine tract (polyQ) within the huntingtin (htt) protein is the root cause of Huntington's disease (HD), but just exactly how this polyQ expansion exerts its devastating effects...
Are We Humans Really That Complex? Just Look at RNA Transcription
One of the big surprises of the genome project was the final tally of how many genes it takes to make a human...
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