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Are two new proteins the missing links to understand the γ-secretase complex? Research presented today at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm suggests as much. Are more components yet to be discovered?
Can coronary artery bypass surgery cause long-term cognitive deficits? New imaging study fuels debate.
Today at the 8th International Conference on Alzheimer’s Disease and Related Disorders, David Holtzman's group reports that the lipid-binding protein ApoJ modulates the formation of amyloid deposits and neuritic toxicity in vivo.
Brian Balin and colleagues at the Philadelphia College of Osteopathic Medicine presented data showing that chlamydia isolated from Alzheimer’s brain, cultured, and then sprayed into the noses of young wild-type BALB/c mice can cause progressive deposition of amyloid plaques...
Stockholm. Read our coverage of the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm, starting with this report of advances in imaging methods and a promising new live amyloid marker.
The immediate future of hormone replacement therapy in the treatment or prevention of diseases does not look promising. A large-scale, prospective study...
In a small, preliminary study, researchers have found that the Alzheimer's drug donepezil (Aricept) can slightly improve the performance of older airline pilots on a flight simulator....
The scientific program of this year’s meeting (in Palm Beach, FL) reflected the high interest of the ASN in neurodegenerative diseases in general, and in Alzheimer's disease (AD) research in particular...
Meeting Report: American Society for Neurochemistry (22-26 June 2002) American Society for Neurochemistry
Two proteins—the recently described aph-1 gene product as well as a novel protein - likely play a role in the production of amyloid-beta (Aβ) via the presenilin/γ-secretase pathway....
New methods are being developed to draw up maps of gene expression in the brain that provide a glimpse of networks of jointly regulated genes and help identify control regions for such networks. Read about this approach tested on a Parkinson's mouse model.
Anyone interested in studying protein-protein interactions in a high-throughput manner may want to read about this new method to use catalytic RNAs that can measure protein-protein interactions in real time.
An advanced online publication in today’s Nature Neuroscience lends support to the hypothesis that mitochondrial damage contributes to the progression of Huntington’s disease...
New observational data from large prospective cohorts in Rotterdam and Chicago supports the link between antioxidant vitamins and a slowing in the onset of AD, but the final answer still awaits prospective trials.
Gabrielle Strobel Interviews Peter Lansbury
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