Mouse Genome Mapped
Members of the International Mouse Genome Consortium reported this week that they have succeeded in making a physical map of this rodent’s genome using, ironically, the sequence of the human genome as a template....
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More on Biomarkers That Signal Longevity
Humans who live longer display the same biomarkers found in laboratory animals who have restricted caloric intake. However, because these human subjects weren't actively restricting their caloric intake, there may be other ways to increase life span in humans...
Go FISH
Researchers at the Albert Einstein College of Medicine in New York demonstrate the use of fluorescence in situ hybridization, or FISH, to measure multiple transcription events in vitro...
Stockholm: There Is No Spatial Paradox!
More news updates from the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm: In a wide-ranging and eloquent presentation, Christian Haass provided several experimental proofs that a small amount of presenilin is detected at the plasma membrane...
Stockholm: The Presenilin Signaling Hub—A RIP-off or the Real Deal?
Ever since Cao and Sudhof provided the first evidence that the intracellular domain of APP (AICD) translocates to the nucleus and may be involved in transcriptional regulation, there has been a reawakening of interest in APP function...
SAGE Genie Manages Gene Expression Data
Over the past decade, new technologies have led to an explosion in the generation of biological data, leaving scientists wishing for a simple way to assimilate and then present the new information...
Stockholm: Could a Whiff of NAP Nip Brain Inflammation in the Bud?
Researchers from Israel presented information about a highly potent peptide that, in rodents, shows promise as a future neuroprotective treatment.
Stockholm: Bad News Official: The Rofecoxib and Naproxen Clinical Trial Has Failed
The latest clinical trial of two non-steriodal anti-inflammatory drugs has shown no efficacy.
Stockholm: Liver Found to Degrade Aβ
The Aβ peptide that circulates in the periphery is degraded not primarily by the kidney, but in the liver, scientists report at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm.
Stockholm: Educated Guessing Game: Which Genes Does “Other” APP Snippet Regulate?
Researchers in several labs are trying to discover the genes whose expression might be controlled by the C-terminal fragment of APP. The answer is not yet in, but read about some clues presented at the 8th International Conference on Alzheimer’s Disease and Related Disorders...
Stockholm: Presenting α-T Catenin: A Long-Awaited Gene on Chromosome 10?
Is α-T catenin the elusive LOAD gene on chromosome 10? Or is it one of several genes? Read about Steve Younkin et al.'s presentation at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm...
Stockholm: Not All NSAIDs Are Equally Good When it Comes to Alzheimer’s
Course Correction on NSAIDs: Reanalysis of Rotterdam data suggest only those NSAIDs that appear to affect AβPP processing protect against AD.
Stockholm: Gold in Them Thar Hills?
Coverage by Keith Crutcher from the Genetics Symposium at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm.
Stockholm: Larger Study Finds Protective Effect of Statin Use
More epidemiological data is being reported at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm to strengthen the association between statin use and lower risk for AD.
Stockholm: Separating Good from Bad Inflammation in AD: Complement Steps into Limelight
Tony Wyss-Coray and colleagues are reporting that disabling the complement cascade, known for its role in innate immunity, causes hippocampal neurodegeneration and exacerbates amyloid deposition. Could this be a way in which microglial activation is beneficial in AD?
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