International CAA Conference 2002
Dave Holtzman Reports on Cerebral Amyloid Angiopathy from England International CAA Conference 2002
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Budding RNAi Therapies, APP Protein Interaction Map Impress at Meeting
Early last month, 118 scientists braved a snowstorm on the Eastern seaboard to gather at Cold Spring Harbor Laboratory on Long Island, New York, for a conference on therapeutic opportunities in neurodegenerative diseases...
Dave Holtzman Reports on Cerebral Amyloid Angiopathy from England
<strong>Raj Kalaria</strong> and <strong>Francine Gervais</strong> organized the Second International Conference on cerebral amyloid angiopathy (CAA), held December 4 to 6 in Newcastle upon Tyne, England...
Rotterdam Study Questions Links between Fat and Dementia Risk
In conflict with a number of recent studies, six-year data from the Rotterdam study of aging failed to show a link between dietary fat and risk of dementia. The results are reported in today’s Neurology...
ALS—Could Stability Rather than Activity of SOD Hold the Key?
Over 100 point mutations in the Cu/Zn superoxide dismutase (SOD) gene have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Exactly why these mutations cause ALS is unclear, but...
New Drug Treats Early Parkinson's Symptoms, Similar to Older One
A new MAO-B inhibitor, rasagiline, proved safe and about as effective as the existing drug, selegiline, in ameliorating symptoms of early Parkinson's. What about its use in Alzheimer's with Parkinsonism?
Parkinson's Proteins and the Proteasome—The Plot Thickens
Read about this latest study linking α-synuclein and parkin to proteasomal degradation, this time addressed in vitro with proteasome inhibitors.
Dendritic Spine Stability—Not So Black and White—or Is That Green and Yellow?
Dendritic spines—tiny protrusions that mediate synaptic contacts between neurons—are present in vast numbers in the mammalian brain (up to ten thousand per neuron)...
Amyloid Formation—One Amino Acid Can Make a Difference
In Alzheimer's brains there exists a complex, dynamic equilibrium among the various soluble and fibrillar forms of the Aβ protein...
Gabrielle Strobel Interviews Susan Lindquist
Susan Lindquist and colleagues published two papers in Science last month, which provide the backdrop and introduction to this interview.
Making Light of Apoptosis
In Alzheimer's, as in many other neurodegenerative diseases, neurons often meet their demise after apoptotic, or programmed cell death pathways have been activated...
Human "Kinome" Mapped
Researchers from the biotechnology company SUGEN (a subsidiary of Pharmacia Corporation) and the Salk Institute in La Jolla, California, report that they have mapped all 518 protein kinases in the human genome...
New Insights into Fibril Formation
Two papers in PNAS add to the growing body of work aimed at understanding the molecular interactions involved in the formation of amyloid fibrils...
Aβ Elevated in Endothelin Converting Enzyme Knockouts
In the December 2 online Journal of Biological Chemistry, researchers extend to mice earlier in-vitro observations linking Aβ degradation to the activity of endothelin converting enzyme (ECE)...
Playing Sonic Hedgehog in the Hippocampus
The developmental signaling protein sonic hedgehog (Shh) appears to play a significant role in regulating the proliferation of adult stem cells, according to a report in yesterday’s Nature Neuroscience...
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