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Last year, three separate laboratories managed to create impressive Parkinson's disease models by transferring human α-synuclein via viral vectors to mice. This approach has now panned out in a primate model...
Two papers published in the 18 February online edition of PNAS reveal structural features that help explain the function of the proposed cholesterol-binding protein NPC2...
In today’s Neuron, scientists at Brigham and Women’s Hospital in Boston, Massachusetts, report that they have devised a biochemical strategy to detect the earliest aggregates of the protein α-synuclein in cultured neurons, mouse brain, and human brain...
A foursome of papers in the February 17 Archives of Neurology continues the shifting debates about three epidemiological questions in Alzheimer’s research...
At the Society for Neuroscience meeting in San Diego in 2001, Peter Davies first presented saitohin, a minigene nested in the tau gene, and his group’s results have since been published. However...
Make that "blue cheese," a massive protein that is expressed in the CNS of <em>Drosophila</em>. In tomorrow’s Journal of Neuroscience, researchers report that <em>blue cheese</em> mutations are involved in progressive neurodegeneration and the accumulation of protein aggregates...
Functional MRI (fMRI) is a powerful technique for measuring subtle magnetic resonance changes in active neurons, but it does have limitations. One commonly used fMRI method called BOLD...
American Neurological Association Annual Meeting: Biomarkers and Mitochondrial Therapy American Neurological Association: 2002 Annual Meeting
Alzforum received several belated comments on some interesting studies presented at the American Neurological Association's annual meeting in New York City last fall. We thus present summaries of these studies...
A flurry of recent papers is shedding new light on the role of proteins containing expanded polyglutamine tracts (polyQ) and their molecular partners, bringing researchers a small step closer toward understanding...
In this month’s Brain, researchers at the Universities of Milan and Genoa, Italy, report that immunizing C57/Bl6 mice with Aβ42 generated an inflammatory response similar to an autoimmune disease in the brains of these mice...
Plaque clearance is a better correlate of neural protection via passive amyloid immunization than soluble amyloid-beta (Aβ) clearance, and this protection is based on Fc receptor-mediated Aβ phagocytosis...
In the January 31 online PNAS, Meir Scheinfeld, Shuji Matsuda, and Luciano D'Adamio of the Albert Einstein College of Medicine in Bronx, New York, show how the carboxyl terminus of AβPP could play a significant role in gene transcription...
Faced with a multibillion dollar deficit, New York State’s Governor George Pataki last week proposed a budget plan that would merge the Nathan Kline Institute for Psychiatric Research in Orangeburg with the New York State Psychiatric Institute in Manhattan...
Transthyretin, like Aβ, is capable of forming amyloid fibrils, and can lead to systemic amyloidosis in families who have inherited particularly fibrillogenic forms of the protein...
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