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An ambitious attempt to link cognitive tests, functional brain imaging, and cell biological assays implicates a polymorphism in brain-derived neurotrophic factor (BDNF) as the source for highly specific memory deficits...
A report in the January 24 online Journal of Biological Chemistry indicates that the Notch ligands Delta and Jagged are also substrates for γ-secretase, the intramembrane aspartyl protease responsible for processing of Notch and AβPP...
Those who can eat as much as they please without gaining avoirdupois may feel smug about a paper in tomorrow’s Science, which reports that mice that lack insulin receptors only in their fat tissue outlive their normal brethren by about 18 percent...
In this week's issue of the Archives of Neurology, collaborators from around Europe propose that a polymorphism in the gene for cholesterol 24-hydroxylase CYP46) is a risk factor for late-onset Alzheimer's...
Collaborative research directed by Floyd E. Bloom of Neurome Inc. and the Scripps Research Institute shows that dramatic changes occur in the brains of mice expressing mutant human forms of AβPP long before any Aβ has been deposited...
Two recent papers from the Journal of Biological Chemistry shed additional light on the roles of APH-1 and PEN-2, two proteins that were only last year identified in screens of the roundworm <em>C. elegans</em> and implicated as members of the presenilin (PS) complex...
The formation of amyloid plaques starts with soluble amyloid-β monomers, which coalesce to form small oligomers, protofibrils, fibrils, and finally the amyloid plaques that pack the intraneural spaces in the brains of Alzheimer's patients...
While the hunt for new Alzheimer’s disease genes continues apace, researchers are still struggling to understand the exact <em>modus operandi</em> of the one prize they have had in hand for years: the lipid carrier protein ApoE.
Research by Jorge Busciglio's lab suggests that focal adhesion (FA) proteins may be critical elements in the production of dystrophic neurites in Alzheimer's disease.
In the January 7 PNAS, researchers from the biopharmaceutical company Scios Inc. reported that sumoylation, the covalent modification of lysine residues by small ubiquitin-like modifier (SUMO) proteins, has a dramatic impact on amyloid β production...
Deficiencies in a component of the reelin developmental signaling cascade produces a mouse that mimics the increased phosphorylation of tau protein seen in Alzheimer's and other neurodegenerative tauopathies...
Genomics, transcriptomics, proteomics, big words describing huge, growing sets of data. The challenge, however, lies not so much in adding more and more to these databases...
In this week's early online edition of PNAS, researchers report that chaperones may play a vital role in regulating protein aggregation in Alzheimer's disease (AD)...
The covalent modification of proteins by phosphorylation of specific amino acids has evolved as a powerful and rapid way for cells to respond to a multitude of internal and external stimuli...
A meta-analysis of clinical trials indicates that cholinesterase inhibitors do more than boost cognitive test scores in Alzheimer's patients. As reported in yesterday’s Journal of the American Medical Association...
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