Dementia with Lewy Bodies: Sharper Image for a Formerly Blurry Disease
At a DLB meeting, scientists reported progress in disentangling the notorious overlap in symptoms and pathology in this quintessential spectrum disease. (Hint: tangles are bad.)
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Lewy Pathology in DLB Spreads Fast, Maybe From the Nose
How α-synuclein aggregates spread, quite possibly starting in the nose in some people, sets DLB apart from its better-known cousins, Alzheimer’s and Parkinson’s.
Genetics of DLB: Setting Up to Fill a Mostly Empty Canvas
When clinicians and pathologists argue, sometimes genetics can settle the dispute. How about DLB?
Yearly Retrospective—Top News of 2015
Alzforum looks back on a year of developments.
Does Free Radical Scavenger Edaravone Slow ALS?
The drug benefits some patients with mild amyotrophic lateral sclerosis, and is approved in Japan.
Supportive Stem Cells Safe for ALS
The modified stem cells might slow disease, too, though the trial was too small to say for sure.
SOD1, Tau Swept Up in Prion-like Biology at ALS Meeting
The prion concept continues to infiltrate the neurodegeneration field, with models of SOD1 propagation and a bevy of tau strains.
Howard Feldman to Breathe New Life Into ADCS
Alzforum spoke with UCSD’s incoming leader for Alzheimer’s research. Where does he want to take the Alzheimer’s Disease Cooperative Study and neurodegeneration research in La Jolla and beyond?
TREM2 Goes Up in Spinal Fluid in Early Alzheimer’s
TREM2 levels tracked with tau, but varied widely among patients and carriers of different mutations, leaving it unclear whether TREM2 helps or hurts.
Tau Takes Center Stage at 10th Human Amyloid Imaging Conference
Using PET, researchers are trying to match tau spread against structural and functional defects.
Human Amyloid Imaging 2016
Tau Takes Center Stage at 10th Human Amyloid Imaging Conference Tau Tracers Track First Emergence of Tangles in Familial Alzheimer’s Shaky Specificity of Tau PET Ligands Stokes Debate at HAI At HAI, Researchers Explore Diagnostic Potential of a Tau Tracer
Will Death in French Drug Trial Lead to Tighter Phase 1 Rules?
While regulators are trying to figure out what went wrong, independent chemists have dug into the mechanism of what may have been a "dirty" drug.
Tau Tracers Track First Emergence of Tangles in Familial Alzheimer’s
Preliminary data suggests a long lag between Aβ and tau deposits as the disease develops.
Traumatic Brain Injury: Aβ Ensues, but Not Quite Alzheimer’s
Scientists find evidence for an Aβ etiology distinct from Alzheimer’s after brain trauma.
Shaky Specificity of Tau PET Ligands Stokes Debate at HAI
Attendees grapple with conflicting binding results
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