Search and Rescue in Parkin Fly Mutants—DA Neurons Are Lost, but Saved by GST
Two years ago, researchers succeeded in breeding fruit flies with mutations in parkin, the gene responsible for most cases of early-onset PD in humans...
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Neurotoxic Homocysteine Metabolite Boosts Intracellular Aβ
The epidemiologic link between elevated blood homocysteine (HC) and Alzheimer disease has spurred the search for the mechanisms by which...
You Gotta Keep 'em Separated—New Strategy for Targeting γ-secretase?
The intramembrane protease activity of γ-secretase is a prime target for therapeutic strategies aimed at treating Alzheimer disease by...
The Cost of Making Memories
In a brief article in today’s Science, Frederic Mery and Tadeusz Kawecki at the University of Fribourg, Switzerland, report that in fruit flies, at least, making...
Tom Fagan Interviews Howard Fillit
Tom Fagan Interviews Howard Fillit
The Theology of Aβ: Presenilins Giveth, and They Taketh Away
Dogma holds that presenilins in the γ-secretase complex beget amyloid-β (Aβ) peptides by cleaving the membrane-bound β amyloid precursor protein (AβPP). But new results show...
Personalized Stem Cells Make Debut
In February 2004, researchers at Seoul National University in Korea surprised the world when they reported...
Lack of Lipoprotein Receptor Boosts Brain ApoE, but Not Aβ
ApoE figures large in Alzheimer disease as the only known genetic risk factor for sporadic AD and an important regulator of...
A New BACE for Immunotherapy
Immunotherapy, through either passive or active immunization, remains a viable and aggressively pursued strategy for...
Atorvastatin, Vaccine Trial Data Published
A mixed bag of epidemiologic studies alternatively hold up and knock down the promise that...
New Lease on Life for Adult Stem Cells
Adult stem cells in the intestine and skin of mice can be induced to...
Mutant Huntingtin—Trojan Horse or Trebuchet?
Mutant proteins that cause neurodegenerative disease, such as amyloid-β precursor protein, parkin, and huntingtin, are produced in many different neurons of the brain. So why do only...
Coaxing Longevity from Catalase
Mice live longer and show signs of delayed aging when they express the antioxidant enzyme...
Aβ—Pinning Down Protofibrils
Amyloid-β (Aβ) comes in many forms, including monomers, oligomers, protofibrils, and fibrils. Protofibrils have emerged as perhaps the most...
Immunotherapy Protects against Synaptic Effects of Soluble Amyloid-β Oligomers
Originally, vaccination with amyloid-β (Aβ) peptides aimed to fight Alzheimer disease by...
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