DJ-1 Dances with Daxx to Keep Neurons Spry
The idea that mutations in the DJ-1 gene cause early-onset Parkinson disease is unquestioned, but just how loss of DJ-1 function leads to destruction of dopamine neurons...
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New Regulatory Mechanism Sees the Light
Light switches come in two types, the on/off and the variable, or dimmer switch. Might phosphorylation switches on proteins work in two ways, also?...
Dynein—Mutations Put the Brakes on Aggregate Clearance
Intracellular protein aggregation is a common theme in neurodegenerative disease. The formation of aggregates is blamed on...
BRIdging Alzheimer Disease and British/Danish Dementias
Amyloids can be formed from many different proteins. In Alzheimer disease (AD), amyloid-β (Aβ) is the culprit, but in other diseases it can be...
Drosophila APP Signals Synapse Formation
Despite the intense scrutiny of the proteolytic processing and products of the amyloid precursor protein (APP) and its role in Alzheimer disease, the normal function of this...
Breaking News: Oxidation of Proteins Leads to DNA Cleavage
Oxygen is a double-edge sword for cells: It is necessary for life, but at the same time it is the source of damaging free radicals that attack DNA, proteins and cell membranes...
New Fat-Free Mouse May Carry Weight
If a fat-free mouse is just what you need to weigh the impact of lipid biology on Alzheimer disease (AD) or other neurodegenerative diseases, then look no further than...
Green Glowing Prions Gather in Golgi
Normal cellular prion protein (PrPc) is easy to spot on the surface of neurons and glia in the CNS by antibody staining. But when the protein converts...
New Neuronal Fare—A Dish of Stem Cells with a Side of Jumping Genes
This week, light from two very different angles was shone on the process of neurodevelopment. Writing in PNAS, researchers described a method to...
American Aging Association: 2005 Annual Meeting
Oakland: Food for Thought at American Aging Association Annual Meeting Oakland: Caloric Restriction Set for Primate Time? Oakland: Are Mitochondria the Key to Longevity? American Aging Association: 2005 Annual Meeting
Oakland: Are Mitochondria the Key to Longevity?
The benefit of caloric restriction (CR) on health and longevity was one of the major themes at the 34th annual meeting of the American Aging Association, held June 3-6 in Oakland, California...
Clearing Aggregates—Macrophages Fall Short for Aβ, but Vaccine Mops Up α-synuclein
Depending on how you look at it, the brain-residing activated microglia observed in Alzheimer disease could be...
Oakland: Caloric Restriction Set for Primate Time?
There is now overwhelming evidence in the scientific literature that caloric restriction (CR)...
Making Heads and Tails of Prion Amyloid
Prions, the infectious agent of mad cow and Creutzfeldt-Jakob disease in humans, are proteins that form...
Oakland: Food for Thought at American Aging Association Annual Meeting
The recent emphasis on caloric restriction (CR) as a means to extend lifespan didn’t stop the American Aging Association from...
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