Amyloid Hypothesis—Closing the Spigot Helps, Temporarily
According to the overflowing bathtub analogy, either a blocked drain (not enough clearance), an oversized faucet (too much production), or a combination, contributes to...
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Aβ and AβPP—Separating the Wheat from the Chaff
Mouse models of Alzheimer disease based on overexpression of Aβ precursor protein may be run-of-the-mill these days, but how...
Amyloid-β Zaps Synapses by Downregulating Glutamate Receptors
The amyloid-β (Aβ) peptide is a destroyer of synapses, and its attack on neurotransmission is blamed for devastating...
No Toxicity in Tau’s Tangles?
In Alzheimer and some other neurodegenerative diseases, the microtubule-associated protein tau weaves a web of neurofibrillary tangles (NFTs) that might...
Cumulating Mitochondrial Mutations Hit Apoptosis Hardest
In today’s Science, an international team of collaborators reports that accumulation of mutations in the mitochondrial genome may...
Dating the Birth of Human Cells—Carbon 14 Runs Rings around Competition
Analysis of growth rings from pine trees in Sweden shows that the proliferation of atomic tests in the 1950s and 1960s led to...
Statin Use and Alzheimer Disease: A Tale of Two Methodologies?
Depending on how you slice the epidemiological pie, the use of cholesterol-lowering statins could appear to...
Painting a Better Picture of Twin Discordance
Twin discordance—the manifestation of vastly different behaviors and susceptibilities to disease despite genetic identity—is a bit of a mystery...
Friend or Foe? Tumor Suppressor p53 Enhances Huntingtin Toxicity
The tumor suppressor p53 is perhaps best known as a cellular watchdog that prevents cancer by...
Memory Enhancement: Two Drugs Better Than One?—Plus, γ-secretase Inhibitor Update
Two heads may be better than one when it comes to solving problems, but two drugs may be better than one when it comes to...
GDNF Powers Neuron Sprouting in Human Brain
For the first time, researchers have witnessed dopaminergic neuron sprouting in a Parkinson disease (PD) patient treated with...
DJ-1 Dances with Daxx to Keep Neurons Spry
The idea that mutations in the DJ-1 gene cause early-onset Parkinson disease is unquestioned, but just how loss of DJ-1 function leads to destruction of dopamine neurons...
New Regulatory Mechanism Sees the Light
Light switches come in two types, the on/off and the variable, or dimmer switch. Might phosphorylation switches on proteins work in two ways, also?...
Dynein—Mutations Put the Brakes on Aggregate Clearance
Intracellular protein aggregation is a common theme in neurodegenerative disease. The formation of aggregates is blamed on...
BRIdging Alzheimer Disease and British/Danish Dementias
Amyloids can be formed from many different proteins. In Alzheimer disease (AD), amyloid-β (Aβ) is the culprit, but in other diseases it can be...
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