Paper Alert: Trafficking Variants Cause BACE Buildup in Axons
In mice lacking the recycling protein GGA3, BACE1 trafficking stalls, local Aβ production increases, and axons swell. Does this explain the neuritic dystrophies seen in early AD?
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Most Detailed Look Yet at Activation States of Human Microglia
Single-cell RNA sequencing of 16,000 live microglia freshly isolated from human brain reveals nine distinct subtypes. One fades in Alzheimer’s. Why?
In Phase 2, Donanemab Curbs Cognitive Decline in Early Alzheimer’s
Among people with early AD, the monoclonal antibody wiped out Aβ plaques and slowed cognitive and functional decline by a third, relative to placebo.
Tau, Speckle Wrecker, Disrupts the Nuclear Home
Disruption of the membraneless organelles may explain toxicity of tau aggregates.
Does ApoE in Neurons Drive Selective Vulnerability in Alzheimer’s?
Certain neurons crank up ApoE expression with age in mice. Ditto with AD progression in people. These same neurons ramp up immune response genes. The shift could foreshadow their demise.
Ingested Aβ Trips Transformation in Microglia
In the plaque-ridden mouse brain, microglia that had taken up Aβ activated a unique gene-expression profile. It faded after microglia were moved to plaque-free environs.
A New Era of Alzheimer’s Treatment
Many Alzheimer’s researchers believe the aducanumab approval heralds the beginning of treatments that slow disease progression—but even they are aghast at the price and hope the drug will not sideline other trials.
Peering Inside Stubby and Mushroom Dendritic Spines
In cultured neurons, these types of spines contain similar amounts and distributions of synaptic proteins, but mushroom spines boast more secretory and trafficking proteins, forging stronger synapses. And, holy moly, the videos!
Getting Too Little Sleep? You May Be Accumulating Amyloid.
Large study confirms that insufficient sleep correlates with amyloid accumulation in otherwise healthy adults. Too much sleep is also bad, but for different reasons.
Davos Alzheimer’s Consortium to Link Global Cohorts
With initial funding secured, DAC is attempting to link Alzheimer's research cohorts, support global clinical trials, and prepare health-care systems around the world.
Flock of New Folds Fills in Tauopathy Family Tree
High-resolution structures of tau fibrils from a variety of tauopathies reveal distinct folds—and important similarities—among syndromes. The folds facilitate a classification of tauopathies.
Plasma Aβ—First Sign of AD, But Tough to Measure Prospectively?
Data shown at CTAD suggests the Aβ42/40 ratio falls in the blood before it does in the CSF, offering perhaps the earliest glimpse at the pathophysiology of Alzheimer's. Measuring that change prospectively might be a tall order.
In Mice, Gene Editing Neutralizes Mutant APP, Keeps Plaques Away
AAV-based CRISPR snipped a piece of mutant APP and limited plaques in mice. Viruses that infiltrate only the CNS—and only neurons there—may facilitate localized gene editing in the brain.
BDNF Val66Met Hastens Tau Phosphorylation in Familial Alzheimer’s
APP or presenilin mutation carriers who also carried the Met66 allele had more p-tau217 at presymptomatic stages, and more p-tau205 at symptomatic stages, than did Val carriers.
In Alzheimer’s, More TREM2 Is Good for You
Longitudinal ADNI data tie higher sTREM2 in CSF to slower cognitive decline, reinforcing the idea that TREM2 activity protects the brain from AD pathology.
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