Better Living Through Polyamines?
In animals, polyamines such as spermidine enhance autophagy, rejuvenate mitochondria, and slow cognitive decline. Buzzword: hypusination. Human data not far behind.
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Stunning Diagnostic Accuracy from a Plasma Protein Panel?
A set of 19 plasma proteins identified clinical Alzheimer’s cases with 97 percent accuracy, and it distinguished mild versus severe dementia. The panel was tested in two small cohorts.
iSILK Tracks Growth of Mouse Plaques at Peptide Level
Using isotope labeling and mass spectrometry imaging, researchers detail how plaques first assemble with an Aβ1-42 core, expand, then subsume Aβ1-38. Plaques start in cortex, then spread to hippocampus.
Is a Waning Locus Coeruleus an Early Sign of Alzheimer’s Disease?
In an aging cohort, weak LC signal intensity on MRI correlated with plaques, tangles, and memory problems.
Survey of Tau Partners Highlights Synaptic, Mitochondrial Roles
An unbiased “interactome” generated from human neurons could shed light on what goes wrong in tauopathies, and help identify new therapeutic targets.
Mild COVID Infection Can Shrink Brain, Speed Cognitive Decline
In some people who had weathered COVID at home, olfactory regions in the brain shrank and executive function slowed. Will these changes resolve or persist?
Surprise! TMEM106b Fibrils Found in Neurodegenerative Diseases
In a game changer for the field, three papers report similar structures for TMEM106b fibrils. One claims they comprise the lion’s share of TDP-43 aggregates.
Aβ Star is Born? Memory Loss in APP Mice Blamed on Oligomer
In a clever bit of sleuthing, Karen Ashe and colleagues appear to have solved the case of the mysterious...
Cryo-EM Unveils Distinct Aβ42 Fibril Structures for Sporadic, Familial AD
Filaments of Aβ42 struck different poses in people with sporadic versus familial AD. The familial AD structure was also found in people with other neurodegenerative diseases, and even in APP knock-in mice.
Dystrophic Neurites Dampen Long-Range Neuronal Signaling
These axonal swellings block action potentials, weakening neural networks in mice. PLD3, an Alzheimer’s disease risk gene, may be involved.
Head-to-Head Study Confirms Plasma p-Tau231 Rises First in Early AD
Plasma p-tau217 and p-tau181 better track amyloid PET, tangles, and subtle cognitive decline.
Alzheimer’s Gene MS4A4A Governs the State of Microglia
A protective variant promotes anti-inflammatory microglia, while a risk variant depletes them.
Listen to Your Gut. It Might Signal Early Alzheimer’s Disease.
In cognitively unimpaired older adults, some gut bacteria correlated with plaques and tangles, but not neurodegeneration.
Fresh Brain Every Friday: Biopsies Transform Alzheimer's Science
In the Finnish city of Kuopio, surgeons and scientists have built a unique protocol. It improves life for people with hydrocephalus—and it banks cortical tissue rife with preclinical pathology and gene variants for Alzheimer's research.
Proteins in Biofluids Foreshadow Dementia by 30 Years
Proteins involved in the extracellular matrix, metabolism, immunity, proteostasis, and synaptic function change in the CSF and plasma up to 30 years before dementia sets in.
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