Heart Failure Drug Drastically Skews Blood Aβ
In people on Entresto, Aβ42 and Aβ40 shot up over six months. The Aβ42/40 ratio fell by a third.
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Alzheimer’s Microglial Risk Gene INPP5D Revs Up Inflammasome
In AD brain, microglia make less of the full-length protein. Loss of INPP5D releases the brakes on inflammation, and may spur microglial phagocytosis.
Plaques Kick Neocortical Neurons into Overdrive, Entangling Tau
A new study casts neuronal hyperexcitability as the link between Aβ aggregation in the neocortex and tau pathology in the medial temporal lobe.
New Atlas Charts Mouse Brain in Exquisite Detail
Researchers wrangled gene expression, epigenetic, and spatial transcriptomic data on 32 million brain cells into the most detailed picture of the mouse brain yet.
‘Slide-tags’ Method Sharpens Spatial Transcriptomics
A new method tags individual cells in a tissue slice with a DNA barcode. This allows isolated cells to be mapped to their original location.
At Holloway Summit, FTD Imaging Shows New Vista
PET tracers for the two main proteopathies of FTD, tau and TDP-43, are now in trials, while AI-enabled analysis of FDG-PET scans discriminates between diseases.
Second Holloway Summit Showcases Intense Search for FTD Biomarkers
Scientists have identified potential fluid and imaging markers that could discriminate between the two main proteopathies of FTD, tau and TDP-43.
Holloway Summit 2023: FTD Biomarkers
Second Holloway Summit Showcases Intense Search for FTD Biomarkers At Holloway Summit, FTD Imaging Shows New Vista To enable clinical trials in frontotemporal dementia, scientists need biomarkers that distinguish its several underlying pathologies. At a r
APOE Christchurch Variant Tames Tangles and Gliosis in Mice
Whether expressing two copies of APOE3 or -E4 with this variant, mice had less tauopathy, gliosis, atrophy. One copy of Christchurch partially protected.
Polygenic Scores Point to Microglia, Astrocytes in Alzheimer's Pathogenesis
Cell-type-specific polygenic risk scores single out microglia as influencers of Aβ and tau pathology, as well as cognitive decline.
Can Organ Aging Clock Foretell Cognitive Decline?
Proteins in human blood flag organ-specific accelerated aging and disease risk. For cognition, 49 proteins better predicted decline then did plasma p-tau 181.
Sought FUS, Found TAF—A New Fibril in Frontotemporal Dementia
Cryo-EM identified TAF15 filaments at the heart of protein aggregates in some FTD cases. Should FDT-FUS be renamed FTD-FET?
Are T Cells to Blame for Cognitive Impairment Caused by Hypertension?
In the dura, these lymphocytes release interleukin 17, activating perivascular macrophages. They curb cerebral blood flow, and mice become forgetful.
Transient Filament Yields AD and CTE Tau Fibrils
Cryo-EM reveals a common conformational progenitor for tau filaments found in Alzheimer’s disease and chronic traumatic encephalopathy.
And Then There Were Five: CSF Proteomics Defines Alzheimer’s Subtypes
Each associates with distinct AD risk variants, brain atrophy, and disease severity.
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