In FTD, TMEM106b Fibrils Tip TDP-43 Dysfunction into Overdrive
Risk variant promotes TMEM106b fibrillization; protective variant discourages it.
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Brain of Woman Who Died on Leqembi Shows Worst-Case Scenario
The patient, an APOE4 homozygote with severe cerebral amyloid angiopathy, developed vascular inflammation and bleeding throughout her brain.
Rising Leqembi Prescriptions Are Straining Clinic Capacity
With several thousand people across the U.S. on the drug, wait times are long, and clinics are hiring. How to meet growing demand?
AD Blood Tests Are Here. Now, Let's Grapple With How to Use Them
Scientists around the globe are studying how best to deploy Alzheimer's plasma tests in the real world. Their focus: primary care.
Paper Alert: p-Tau217 Blood Test Predicts Plaques, Tangles Over Time
ALZpath’s assay detected an annual rise in plasma phospho-tau217 in amyloid-positive people, with the steepest increase in those who also have tangles.
Cholesterol Metabolite Ups Estrogen Signaling to Keep Females Sharp
The enzyme cholesterol 24-hydroxylase protected against cognitive decline and tau pathology—but only in females.
FDA Approves BrainSee, AI Software That Purportedly Predicts AD
The software could improve prognosis, speed referrals, for people with MCI, the developer claims.
Mouse Model LOADs on the Risk Factors
When LOAD2 mice, which carry Alzheimer’s risk variants, eat a fatty diet, their proteomes change, their neurons die, and their memories fail. All sans amyloid plaques.
Per Simoa, CSF p-tau205 Tracks with Tangles, Disease Progression
The biomarker may signal tau’s early days of entanglement, and serve as a useful disease staging indicator, according to a new immunoassay.
Mind the GAP—Synaptic Protein in CSF Signals Tau Spread
Growth-associated protein 43 in the CSF identified people who accumulated tangles fastest. These spread through connected brain regions.
2023—A Bumper Year for the Treatment and Science of Alzheimer's
Last summer saw a first: the traditional approval of a disease-modifying Alzheimer's therapy. Solid progress on biomarkers, and a flourishing of basic research, made for a good year.
Do Neurons Dilate Blood Vessels Via Synaptic Signaling?
Axons touch arterioles, releasing glutamate that makes smooth muscle cells relax. This increases cerebral blood flow in mice.
Similar Risk Factors Found for Young- and Late-Onset Dementia
A U.K. Biobank analysis generated 15 risk factors for young-onset dementia. Many factors also correlated with late-onset disease.
Heart Failure Drug Drastically Skews Blood Aβ
In people on Entresto, Aβ42 and Aβ40 shot up over six months. The Aβ42/40 ratio fell by a third.
Alzheimer’s Microglial Risk Gene INPP5D Revs Up Inflammasome
In AD brain, microglia make less of the full-length protein. Loss of INPP5D releases the brakes on inflammation, and may spur microglial phagocytosis.
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