Neuronal Pentraxin 2 Binds Complement Protein, Protects Synapses
NPTX2 binds complement C1q, disrupting signals to microglia to destroy synapses.
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Bringing Aduhelm—and Antibodies to Come—Into Practice
Scientists are refining safety and biomarker disclosure protocols, and are preparing to collect data on how well the new drugs work.
By Unleashing Microglial cGAS, Tau STINGs Neurons
cGAS and STING initiate a type I interferon response, which weakens neurons’ resilience to tau pathology.
Brain Within a Brain? Nested Organoids a New Way to Study Human Microglia
Transplanting a human cerebral organoid containing microglia into a mouse brain allows the cells to thrive in something close to their natural environment.
CMS Sticks to Its Guns on Amyloid Immunotherapy Coverage
The agency reiterated its earlier decision that traditionally approved amyloid antibodies will be covered if physicians enter data into a patient registry.
A Failing Sleep Neuropeptide Hypes Up Hippocampus
In amyloidosis mice, decline of the hypothalamic melanin-concentrating hormone system jacks up neuronal activity, and contributes to sleep problems.
Shape Your Microbiome. You’ll Live Longer, Scientists Say
The more a person’s gut microbiome becomes individualized with age, the longer that person's lifespan and the better his or her health, say scientists.
Does Taurine Deficiency Accelerate Aging in Mice, Monkeys?
Feeding taurine to mice and monkeys increased the lifespan of the former and reduced signs of aging in both.
Give BACE Inhibitors a Second Chance?
Between basic researchers and clinicians, momentum is growing to test BACE inhibition again. This time, at low doses.
Spying on α-Synuclein Inclusions: PET Tracers Inch Closer to Success
A crop of new PET tracers that bind α-synuclein aggregates shows promise in tissue samples and in animal models. Will they prove potent enough for brain imaging?
Meet the Switching Mice: They Flip Their Glia APOE4 to APOE2
Swapping allele expression in astrocytes lowered amyloid load, lessened gliosis, and improved memory. This works even after amyloidosis is in full swing.
Cognitive Tests Taken at Home Are on Par with In-Clinic Assessments
Six commonly used tests accurately detected dementia, even preclinical cognitive slippage, when given over video chat or face-to-face.
Missing ‘Lnc’? Long Noncoding RNAs Bind Tau, Tame Stress Granules
FTLD-causing mutations in tau turned down expression of lncRNAs including SNHG8. This goaded TIA1 to form stress granules, bringing tau along for the ride.
In Alzheimer’s, Tau Oligomers in Synapses Act as ‘Eat Me’ Signal
The oligomers beckon microglia and astrocytes to prune dendrites. This correlates with cognitive decline.
Stunning Detail: Single-Cell Studies Chart Genomic Architecture of AD
Resilient and vulnerable interneurons mark different stages of Alzheimer's. Gene regulation crumbles in late stages. Microglial states change with epigenomic shifts.
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